Pennsylvania Sun news

Export man gets prison for child porn murder threat

A western Pennsylvania man who threatened to have a female U.S. postal inspector investigating him for child pornography possession gang-raped and murdered was sentenced Tuesday to 38 months in ...
Number one draft pick signs with Pirates

The Pirates announced the signing of their number one draft choice. The official release from the team follows. Look for coverage of the announcement and the introduction of Resse McGuire on Channel 4 Action News at ...
Bellefonte man sentenced to 30 years in prison for child sex abuse

A Bellefonte man will spend at least 30 years behind bars for sexually abusing two young girls between 2001 and 2011. Jeffrey Storms, 42, was sentenced Tuesday by President Judge Thomas King Kistler to serve the next 30 to 60 years in state prison. Storms was also found to be sexually violent predator, and if he is paroled, he would have to register a sex offender for the rest of his life, said ...
Chrysler relents agrees to recall 2.7 million Jeeps

Chrysler Group reversed course and agreed to a recall of 2.7 million Jeeps Tuesday, giving in to the government's request in the final hours before a ...
Mayor Ravenstahl’s former bodyguard appears before grand jury

Former Ravenstahl bodyguard Fred Crawford (right) and his attorney Bob Stewart make their way to the federal courthouse, Downtown, Tuesday, June 18, 2013, to appear before a grand ...

Movie Review

Bad Education (La mala educación)

In Bad Education (La mala educacin), Pedro Almodvars deeply saturated noir/melodrama pastiche, past and present, fiction, and truth are so intertwined and turned around that any sense of mystery the film develops is ultimately subsumed by its incessant obsession with unkno ... ...

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New law ensures crime victims and families can speak up during parole process

HARRISBURG -- Crime victims and their families on Tuesday earned the right to speak to the Board of Probation and Parole when it considers releasing a person who perptrated a crime against ...
Gov. Corbett Signs Bill Limiting Abortion Coverage in Pennsylvania

Pennsylvania is joining about 20 other states in limiting coverage of abortions under health care insurance policies offered in a federally-run insurance ...
Ravenstahls ex-bodyguard arrives at federal courthouse

Mayor Luke Ravenstahl makes a rare public appearance, but keeps mum on a federal investigation of the Pittsburgh Bureau of Police that keeps hovering around his ...
Man armed with knife robs GetGo in East McKeesport

Police are investigating whether an armed robbery at an East McKeesport GetGo on Tuesday morning is related to a similar incident in nearby ...
AP PennDOT withholds funding plan from public

HARRISBURG, Pa. - The Pennsylvania Department of Transportation has built a website that compares competing plans to spend billions of dollars in new transportation money, but it's refusing to release similar information to the public, which will pay for chosen projects.Department officials gave lawmakers access to the password-protected website almost two weeks ago but refused again ...

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Making headlines

Our nuclear programmes are completely transparent. But we are ready to show greater transparency and make clear for the whole world that the steps of the Islamic Republic of Iran are completely within international frameworks. The sanctions are unfair, the Iranian people are suffering, and our (nuclear) activities are legal. These sanctions are illegal and only benefit Israel.

Hassan Rouhani

Iran's president-elect was speaking after his historic election victory.

Hotel Review

Beach Rotana Hotel & Towers

I could not find the Web site for this hotel, and it was not listed on any of the Internet ...

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Have Your Say

Should tax havens be forced to lift their shroud of secrecy?

Pennsylvania Sun

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Featured Story

Protein key to breast cancer recurrence identified

Researchers at the Perelman School of Medicine, University of Pennsylvania have identified a key molecular player in recurrent breast cancer - a finding that suggests potential new therapeutic strategies.

The study, performed in the laboratory of Lewis A. Chodosh MD, PhD, chair of Cancer Biology and director of Cancer Genetics at the Abramson Family Cancer Research Institute, implicates the tumor suppressor protein Par-4 in recurrent breast cancer.

Par-4 is downregulated in recurrent tumors, and knocking the gene's expression down accelerates tumor recurrence in a mouse model of recurrent breast cancer. Conversely, overexpressing Par-4 delays the onset of tumor recurrence.

Data from human breast cancer patients confirm these findings. The authors analyzed patient tumors from the I-SPY 1 TRIAL, a clinical trial that measured tumor gene expression patterns and response to neoadjuvant chemotherapy.

They found that Par-4 expression is low in "residual disease" (that portion of a tumor that survives chemotherapy) compared to the primary tumor prior to treatment, and that women with low Par-4 levels in their primary tumors tend to respond less well to treatment and are more likely to experience a relapse. ...