Pennsylvania Sun news

Browns hit in 9th lifts Phillies over Nationals

Philadelphia Phillies' Domonic Brown hits the game-winning RBI-single off Washington Nationals relief pitcher Fernando Abad in the ninth inning of a baseball game, Monday, June 17, 2013, in Philadelphia. Philadelphia won 5-4. (AP Photo/Matt ...
Bruins beat Blackhawks 2-0 lead Cup finals 2-1

Boston Bruins goalie Tuukka Rask (40), of Finland, defends the net as ice crystals swirl around him during the second period in Game 3 of the NHL hockey Stanley Cup Finals against the Chicago Blackhawks in Boston, Monday, June 17, 2013. (AP Photo/Bruce Bennett, ...
US waiting seeing with Irans new chief

The U.S. State Department said Monday it wasn't surprised that Iran's newly elected president, Hassan Rouhani, said that Syrian President Bashar al-Assad should stay in power until ...
Royals edge Indians 2-1 on wild pitch

Pinch-runner Elliot Johnson scored from third base on a wild pitch by reliever Matt Albers in the ninth inning, giving the Kansas City Royals a 2-1 win over the Cleveland Indians on Monday ...
Paille Bergeron put Bruins ahead 2-0 after 2nd

View Photo Associated Press/Elise Amendola - Chicago Blackhawks defenseman Niklas Hjalmarsson, bottom, of Sweden, takes down Boston Bruins left wing Daniel Paille (20) during the second period in Game 3 of the NHL ...

Movie Review

Gladiator

After several years of major releases, it has finally become clear what the DreamWorks strategy is: Each summer, they try to revive some long-dormant Hollywood genre by giving it a splashy, special-effects-laden modern spin. In 1998, they successfully revived the flag-waving World War II epic with Steven Spielberg's "Saving Private Ryan." Last summer, they tried (with considerably less success) t ... ...

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Mt. Lebanon School Board OKs work for high school renovation project

The Mt. Lebanon School Board on Monday night unanimously approved $354,934 in change orders for the high school renovation project, despite criticism from some residents at the ...
Police chase ends with crash in Richland

One man was flown to a Pittsburgh hospital following the second crash that occurred about 7:30 p.m. on Route 8, also known as William Flynn Highway, in front of an entrance to the Northtowne Square shopping center, said Northern Regional Police Chief Robert Amann. The person who police were chasing was taken into custody there, he ...
Blue Jays beat Rockies 2-0 for 6th straight win

Toronto Blue Jays pitcher Josh Johnson works against the Colorado Rockies in the first inning of a baseball game in Toronto, Monday June 17, 2013. (AP Photo/The Canadian Press, Frank ...
Hossa hurt Chicago and Boston tied 0-0 after 1st

Boston Bruins fans pass a large banner through the stands before Game 3 of the NHL hockey Stanley Cup Finals against the Chicago Blackhawks in Boston, Monday, June 17, 2013. (AP Photo/Elise ...
US releases names of Guantanamo indefinite detainees

The names of dozens of detainees held at the military prison at Guantanamo Bay, Cuba, were released for the first time on Monday after a newspaper sued the federal government for the ...

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Making headlines

Our nuclear programmes are completely transparent. But we are ready to show greater transparency and make clear for the whole world that the steps of the Islamic Republic of Iran are completely within international frameworks. The sanctions are unfair, the Iranian people are suffering, and our (nuclear) activities are legal. These sanctions are illegal and only benefit Israel.

Hassan Rouhani

Iran's president-elect was speaking after his historic election victory.

Hotel Review

Amora Hotel Jamison Sydney

This hotel is located right in the heart of the CBD of Sydney in Jamison Street. The hotel neighbours the ...

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Should tax havens be forced to lift their shroud of secrecy?

Pennsylvania Sun

Pennsylvania Sun | Reporting the News in Pennsylvania

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Featured Story

Protein key to breast cancer recurrence identified

Researchers at the Perelman School of Medicine, University of Pennsylvania have identified a key molecular player in recurrent breast cancer - a finding that suggests potential new therapeutic strategies.

The study, performed in the laboratory of Lewis A. Chodosh MD, PhD, chair of Cancer Biology and director of Cancer Genetics at the Abramson Family Cancer Research Institute, implicates the tumor suppressor protein Par-4 in recurrent breast cancer.

Par-4 is downregulated in recurrent tumors, and knocking the gene's expression down accelerates tumor recurrence in a mouse model of recurrent breast cancer. Conversely, overexpressing Par-4 delays the onset of tumor recurrence.

Data from human breast cancer patients confirm these findings. The authors analyzed patient tumors from the I-SPY 1 TRIAL, a clinical trial that measured tumor gene expression patterns and response to neoadjuvant chemotherapy.

They found that Par-4 expression is low in "residual disease" (that portion of a tumor that survives chemotherapy) compared to the primary tumor prior to treatment, and that women with low Par-4 levels in their primary tumors tend to respond less well to treatment and are more likely to experience a relapse. ...