Pennsylvania Sun news

Saunders WP scores only run in Ms loss to Angels

In a game in which every pitch was critical, the only run scored on a wild pitch. That's all that separated C.J. Wilson and Joe Saunders.Wilson outdueled the former Angels left-hander with seven innings of two-hit ball, leading Los Angeles to a 1-0 victory over the Seattle Mariners on Wednesday night."It's one of those things where runs were hard to come by tonight," Saunders ...
Youth leagues try to rein in bad news parents

View Photo Associated Press/Martha Irvine - A young batter takes a swing as a father who's a coach supervises at a youth baseball game in Buffalo Grove, Ill. on Monday June 10, 2013. Earlier in the month, park ...
N. Huntingdon road remains private — for now

"We all want the road to be public, because it is being used by the public," said Tarosky, from Lincoln Hills Realty Associates. "If it is public, then we are not subject to PennDOT regulations requiring us to do off-site ...
Illegal dumping case continued

A preliminary hearing was continued for three weeks for a North Versailles Township man cited for illegal dumping of hundreds of tires on a Crestas Terrace ...
Police charge 3 in burglary

Police made the arrest after reviewing video surveillance footage of the alleged burglary in process, which was discovered by a homeowner who went home for ...

Movie Review

Beowulf [DVD]

All hail technology and what it hath wrought! Bow down at the altar of infinitely malleable pixels and the bounty they provide: Impossible visuals! Epic landscapes! Monsters that heretofore have only resided in mans imagination! And slightly rubbery-looking humans who in close-up offer every nua ... ...

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Students learn skills through simulation lab

McKeesport Area High School's Allied Health students pose at the district's Career and Technology Center with instructors Donna Maguire and Antonietta Stolic, at left, and McKeesport Hospital Foundation executive director Michele Matuch and school director Tom ...
AP EXCLUSIVE Taliban offer to free US soldier

ISLAMABAD, Pakistan (AP) -- The Afghan Taliban say they are ready to hand over a U.S. soldier held captive since 2009 in exchange for five of their senior operatives being held at the Guantanamo Bay ...
Police Disabled Pa. man who died suffered neglect

SCRANTON, Pa. - A 32-year-old Pennsylvania man with Down syndrome was so severely neglected by his family that his body was covered in scabies and he weighed just 69 pounds when he died, police said in charging his mother and two sisters with murder.Robert Gensiak had open sores down to the bone at the time of his death March 20. He was taken to the hospital a day earlier because he was only ...
Cumpton looks to force series split in second start

There's been plenty of bad blood between the Pirates and Reds this season. And one result of it may have something to do with Brandon Phillips' recent struggles. Since being plunked with a Tony Watson fastball on the forearm on June 1, Phillips is 10-for-56 (.179) in 13 games. He missed four with an injury resulting from the pitch and still has a welt on his arm. But Phillips may ...
Leechburg Area coaches mixed about move to Heritage

Half of Leechburg Area coaches are neutral on whether the district should move its sports teams out of the WPIAL and into the Heritage ...

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Making headlines

Our nuclear programmes are completely transparent. But we are ready to show greater transparency and make clear for the whole world that the steps of the Islamic Republic of Iran are completely within international frameworks. The sanctions are unfair, the Iranian people are suffering, and our (nuclear) activities are legal. These sanctions are illegal and only benefit Israel.

Hassan Rouhani

Iran's president-elect was speaking after his historic election victory.

Hotel Review

Metro Hotel on Pitt

A truly affordable hotel in Sydney, with stylish decor, great location and in-house snazzy brasserie? If the notion of affordable ...

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Should tax havens be forced to lift their shroud of secrecy?

Pennsylvania Sun

Pennsylvania Sun | Reporting the News in Pennsylvania

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Featured Story

Protein key to breast cancer recurrence identified

Researchers at the Perelman School of Medicine, University of Pennsylvania have identified a key molecular player in recurrent breast cancer - a finding that suggests potential new therapeutic strategies.

The study, performed in the laboratory of Lewis A. Chodosh MD, PhD, chair of Cancer Biology and director of Cancer Genetics at the Abramson Family Cancer Research Institute, implicates the tumor suppressor protein Par-4 in recurrent breast cancer.

Par-4 is downregulated in recurrent tumors, and knocking the gene's expression down accelerates tumor recurrence in a mouse model of recurrent breast cancer. Conversely, overexpressing Par-4 delays the onset of tumor recurrence.

Data from human breast cancer patients confirm these findings. The authors analyzed patient tumors from the I-SPY 1 TRIAL, a clinical trial that measured tumor gene expression patterns and response to neoadjuvant chemotherapy.

They found that Par-4 expression is low in "residual disease" (that portion of a tumor that survives chemotherapy) compared to the primary tumor prior to treatment, and that women with low Par-4 levels in their primary tumors tend to respond less well to treatment and are more likely to experience a relapse. ...