Pennsylvania Sun news

Woman charged with running over young mother in love triangle

, 28, is facing a number of assault charges as well as criminal attempted homicide after state police in Greensburg say she intentionally ran over Katelin Hiltabidel in an East Huntingdon Township yard Tuesday ...
Thousands of tea party activists rip IRS at rally

Thousands of tea party activists gathered Wednesday outside the Capitol in loud protest of the Internal Revenue Service, seeking to keep the beleaguered agency's scandal afloat nearly six weeks after the news first ...
Corbett signals hell try to help Philly schools

HARRISBURG, Pa. (AP) -- Gov. Tom Corbett is signaling that he's engaged in efforts to help the financially troubled Philadelphia School District, which is in the midst of shedding 20 percent of its ...
Funding for key gas drilling health study stalled

Geisinger Health System spokeswoman Amanda O'Rourke said Wednesday the $1 million grant that was announced in February 2012 remains the only funding for a project that was projected to cost at least $25 ...
Army National Guardsman sues Target claims he was fired while preparing for deployment

Andrew Lanier remembers well the date that Target fired him from his stock job at its North Fayette store: Oct. 31, 2011. That's the day he learned his mission was canceled, after two weeks of training at Ft. Picket, Va., as part of his preparation for deployment to ...

Movie Review

Murder by Numbers

Never as disturbing or evocative as it would like to be, Murder by Numbers plods through its psychological murder-mystery trappings like well-worn clothes, and the edges are definitely starting to look frayed. There are the roots of something truly disquieting here, but the film's slick, but routine Hollywood polish keeps it level and unmemorable. ...

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City police investigating whether officer who gave ride to mayor’s ex-bodyguard broke any department regulations

Acting Pittsburgh police Chief Regina McDonald on Wednesday launched an internal investigation into whether a Zone 2 police officer broke any department regulations when he gave a ride to Mayor Luke Ravenstahl's former bodyguard after he testified before a federal grand ...
Statement on Judge James Ruling

While we are disappointed that our Motion for Partial Summary Judgment against the SEA was not granted, we look forward to the opportunity to present our full case to Judge James. We remain confident in our legal and factual position. Our Lease clearly sets out the obligations the SEA agreed to perform regarding our proposed improvements at Heinz Field. We are simply asking that the SEA live up ...
Two people shot on Amanda Street in Knoxville

A Pittsburgh police officer talks to witnesses Wednesday afternoon outside a hair salon where police believe a confrontation started that led to a shooting on Amanda Street in ...
Market Square Farmer’s Market expanding

The Market Square Farmer's Market is expanding into the adjoining PPG Place walkway between Fourth Avenue and Market Square beginning this ...
NJ Gov. Christie is still a Dallas Cowboys fan

SAYREVILLE, N.J. -; New Jersey Gov. Chris Christie surprised some schoolchildren when he told them his favorite football team is the Dallas ...

More Pennsylvania Sun news

Making headlines

Our nuclear programmes are completely transparent. But we are ready to show greater transparency and make clear for the whole world that the steps of the Islamic Republic of Iran are completely within international frameworks. The sanctions are unfair, the Iranian people are suffering, and our (nuclear) activities are legal. These sanctions are illegal and only benefit Israel.

Hassan Rouhani

Iran's president-elect was speaking after his historic election victory.

Hotel Review

Metro Hotel on Pitt

A truly affordable hotel in Sydney, with stylish decor, great location and in-house snazzy brasserie? If the notion of affordable ...

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Should tax havens be forced to lift their shroud of secrecy?

Pennsylvania Sun

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Featured Story

Protein key to breast cancer recurrence identified

Researchers at the Perelman School of Medicine, University of Pennsylvania have identified a key molecular player in recurrent breast cancer - a finding that suggests potential new therapeutic strategies.

The study, performed in the laboratory of Lewis A. Chodosh MD, PhD, chair of Cancer Biology and director of Cancer Genetics at the Abramson Family Cancer Research Institute, implicates the tumor suppressor protein Par-4 in recurrent breast cancer.

Par-4 is downregulated in recurrent tumors, and knocking the gene's expression down accelerates tumor recurrence in a mouse model of recurrent breast cancer. Conversely, overexpressing Par-4 delays the onset of tumor recurrence.

Data from human breast cancer patients confirm these findings. The authors analyzed patient tumors from the I-SPY 1 TRIAL, a clinical trial that measured tumor gene expression patterns and response to neoadjuvant chemotherapy.

They found that Par-4 expression is low in "residual disease" (that portion of a tumor that survives chemotherapy) compared to the primary tumor prior to treatment, and that women with low Par-4 levels in their primary tumors tend to respond less well to treatment and are more likely to experience a relapse. ...