Pennsylvania Sun news

Police Disabled Pa. man who died suffered neglect

SCRANTON, Pa. - A 32-year-old Pennsylvania man with Down syndrome was so severely neglected by his family that his body was covered in scabies and he weighed just 69 pounds when he died, police said in charging his mother and two sisters with murder.Robert Gensiak had open sores down to the bone at the time of his death March 20. He was taken to the hospital a day earlier because he was only ...
Cumpton looks to force series split in second start

There's been plenty of bad blood between the Pirates and Reds this season. And one result of it may have something to do with Brandon Phillips' recent struggles. Since being plunked with a Tony Watson fastball on the forearm on June 1, Phillips is 10-for-56 (.179) in 13 games. He missed four with an injury resulting from the pitch and still has a welt on his arm. But Phillips may ...
Leechburg Area coaches mixed about move to Heritage

Half of Leechburg Area coaches are neutral on whether the district should move its sports teams out of the WPIAL and into the Heritage ...
Workshop cautions classrooms of unknown toxins in everyday items

The "Healthy Body. Healthy Home. Healthy Planet." workshop, offered at McKeesport Area High School in the spring, cautioned students on known toxins in household products, toiletries and ...
Monessen mayor takes heat at council meeting

Michael Aldrich, the brother of recently retired Monessen police Lt. Lloyd "Yo Yo" Aldrich, accused the mayor of racial discrimination for not promoting the officer to captain before he retired in April after more than 40 years on the ...

Movie Review

Beowulf [DVD]

All hail technology and what it hath wrought! Bow down at the altar of infinitely malleable pixels and the bounty they provide: Impossible visuals! Epic landscapes! Monsters that heretofore have only resided in mans imagination! And slightly rubbery-looking humans who in close-up offer every nua ... ...

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McKeesport Area High School’s Allied Health students got together at the district’s Career and Technology Center with instructors Donna Maguire and Antonietta Stolic at left and McKeesport Hospital Foundation executive director Michele Matuc

Combining a spring field trip with grant-funded resources, Allied Health students at McKeesport Area Career and Technology Center will gain practical skills through health care ...
Rejuvenated Blackhawks tie series 2-2 with OT win

Boston Bruins goalie Tuukka Rask (40), of Finland, gets up after the winning goal by Chicago Blackhawks Brent Seabrook, not shown, crossed into the net during the first overtime period in Game 4 of the NHL hockey Stanley Cup Finals, Wednesday, June 19, 2013, in Boston. Chicago won 6-5. Chicago won ...
Cards foil Jacksons bid for 3rd straight win 4-1

ST. LOUIS - Edwin Jackson believes he knows what ailed him at the start of his tenure with the Chicago Cubs."Earlier, I felt like I was kind of mechanical, kind of too much in a bubble," he said. "You have to go back to having fun."The Cardinals kept Jackson from having much fun in his bid for a third straight victory. Yadier Molina hit his fifth home run and Jake Westbrook ...
Sale struggles for White Sox in 7-4 loss to Twins

MINNEAPOLIS - Chris Sale dodged danger when a sharp comebacker in the second inning grazed his glove, then his arm and finally his chin.It eventually turned into a rough night. Even the ace of the sputtering Chicago White Sox couldn't stay out of trouble in this game.Justin Morneau homered for the first time in almost two months, a two-run shot that helped the Minnesota Twins to a 7-4 ...
Hamels hoping start vs. Mets begins turnaround

The story of the 2013 Phillies has been their inability to escape mediocrity, as they've hovered around the .500 mark almost all season. Every step forward, it seems, has been followed by a step back, and they haven't been more than one game above the break-even mark all year. They'll look to start turning things around on Friday against a familiar foe, the New York Mets, when ...

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Making headlines

Our nuclear programmes are completely transparent. But we are ready to show greater transparency and make clear for the whole world that the steps of the Islamic Republic of Iran are completely within international frameworks. The sanctions are unfair, the Iranian people are suffering, and our (nuclear) activities are legal. These sanctions are illegal and only benefit Israel.

Hassan Rouhani

Iran's president-elect was speaking after his historic election victory.

Hotel Review

Metro Hotel on Pitt

A truly affordable hotel in Sydney, with stylish decor, great location and in-house snazzy brasserie? If the notion of affordable ...

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Should tax havens be forced to lift their shroud of secrecy?

Pennsylvania Sun

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Featured Story

Protein key to breast cancer recurrence identified

Researchers at the Perelman School of Medicine, University of Pennsylvania have identified a key molecular player in recurrent breast cancer - a finding that suggests potential new therapeutic strategies.

The study, performed in the laboratory of Lewis A. Chodosh MD, PhD, chair of Cancer Biology and director of Cancer Genetics at the Abramson Family Cancer Research Institute, implicates the tumor suppressor protein Par-4 in recurrent breast cancer.

Par-4 is downregulated in recurrent tumors, and knocking the gene's expression down accelerates tumor recurrence in a mouse model of recurrent breast cancer. Conversely, overexpressing Par-4 delays the onset of tumor recurrence.

Data from human breast cancer patients confirm these findings. The authors analyzed patient tumors from the I-SPY 1 TRIAL, a clinical trial that measured tumor gene expression patterns and response to neoadjuvant chemotherapy.

They found that Par-4 expression is low in "residual disease" (that portion of a tumor that survives chemotherapy) compared to the primary tumor prior to treatment, and that women with low Par-4 levels in their primary tumors tend to respond less well to treatment and are more likely to experience a relapse. ...