Pennsylvania Sun news

Giant sinkhole forces West View road to shut down

Repairs are being made at Perry Highway near Center Avenue after the sinkhole expanded from the size of a pothole to a giant hole measuring about 15 feet long and 20 feet ...
Woman robbed at car on Squirrel Hill street

Pittsburgh police are asking for help to identify two suspects in the afternoon robbery of a woman on a street in what has generally been considered a safe Squirrel Hill ...
Feds Pittsburgh brothers ran Craiglist tixx scam

PITTSBURGH - A federal grand jury has charged two Pittsburgh brothers with scamming more than 250 people out of more than $70,000 by offering to sell event tickets over the online want-ad site, Craigslist.Online court records don't list attorneys for 29-year-old Daniel Isabella Jr. and 22-year-old David Isabella, neither of whom has a listed telephone.An indictment on charges of conspiracy ...
Father son acquitted in NY of sex trafficking

NEW YORK - A father and son who acknowledged they were pimps were acquitted Wednesday of sex trafficking charges after several prostitutes testified they were treated well.A Manhattan judge found George Vincent Sr. and his son, George Vincent Jr., guilty of less-serious charges of promoting prostitution and money laundering. The two hadn't denied they were pimps but insisted they never ...
Judge orders Scott man to spend life in prison for fatally shooting man in Hill District

An Allegheny County judge on Wednesday ordered a Scott man to spend the rest of his life in prison without the possibility of parole for fatally shooting a man in the Hill ...

Movie Review

Floating Weeds / A Story of Floating Weeds [DVD]

For auteurist critics, A Story of Floating Weeds (Ukigusa monogatari), Yasujiro Ozus 1934 film about a traveling troupe of actors, is considered the moment in which he came into his own, both aesthetically and thematically. He was already a prolific fi ... ...

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Firefighters quickly extinguish Downtown restaurant fire no one hurt

Dispatchers sent fire crews at 8:58 a.m. to a two-alarm fire at Tavern 245 on Fourth Ave. A ladder and small hose stretched to the roof of the building, where there is seating. Four fire trucks blocked Fourth Avenue near Wood ...
3 former Carlow employees claim age discrimination in firings

Three former employees claim in a federal lawsuit filed Wednesday that Carlow University on Sept. 24 fired them and two other women because they were all over the age of ...
‘Green thumb’ robber steals cash greenhouse plants

State police in Greensburg said an armed robber held up the Amenity Farm and Greenhouse along Mt. Pleasant Road in the village of United, Mt. Pleasant ...
Pennsylvania Attorney General focuses on drug trafficking

Pennsylvania Attorney General Kathleen Kane recently announced her support for the creation of a new, statewide law enforcement unit that would specifically ...
The Allegheny County 2013 Fun Guide is out

Concerts, nature programs, movies, sports clinics, plays, athletic events, classes, historical tours and fundraisers are all included in the Fun ...

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Making headlines

Our nuclear programmes are completely transparent. But we are ready to show greater transparency and make clear for the whole world that the steps of the Islamic Republic of Iran are completely within international frameworks. The sanctions are unfair, the Iranian people are suffering, and our (nuclear) activities are legal. These sanctions are illegal and only benefit Israel.

Hassan Rouhani

Iran's president-elect was speaking after his historic election victory.

Hotel Review

Metro Hotel on Pitt

A truly affordable hotel in Sydney, with stylish decor, great location and in-house snazzy brasserie? If the notion of affordable ...

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Should tax havens be forced to lift their shroud of secrecy?

Pennsylvania Sun

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Featured Story

Protein key to breast cancer recurrence identified

Researchers at the Perelman School of Medicine, University of Pennsylvania have identified a key molecular player in recurrent breast cancer - a finding that suggests potential new therapeutic strategies.

The study, performed in the laboratory of Lewis A. Chodosh MD, PhD, chair of Cancer Biology and director of Cancer Genetics at the Abramson Family Cancer Research Institute, implicates the tumor suppressor protein Par-4 in recurrent breast cancer.

Par-4 is downregulated in recurrent tumors, and knocking the gene's expression down accelerates tumor recurrence in a mouse model of recurrent breast cancer. Conversely, overexpressing Par-4 delays the onset of tumor recurrence.

Data from human breast cancer patients confirm these findings. The authors analyzed patient tumors from the I-SPY 1 TRIAL, a clinical trial that measured tumor gene expression patterns and response to neoadjuvant chemotherapy.

They found that Par-4 expression is low in "residual disease" (that portion of a tumor that survives chemotherapy) compared to the primary tumor prior to treatment, and that women with low Par-4 levels in their primary tumors tend to respond less well to treatment and are more likely to experience a relapse. ...