Pennsylvania Sun news

Rejuvenated Blackhawks tie series 2-2 with OT win

Boston Bruins goalie Tuukka Rask (40), of Finland, gets up after the winning goal by Chicago Blackhawks Brent Seabrook, not shown, crossed into the net during the first overtime period in Game 4 of the NHL hockey Stanley Cup Finals, Wednesday, June 19, 2013, in Boston. Chicago won 6-5. Chicago won ...
Cards foil Jacksons bid for 3rd straight win 4-1

ST. LOUIS - Edwin Jackson believes he knows what ailed him at the start of his tenure with the Chicago Cubs."Earlier, I felt like I was kind of mechanical, kind of too much in a bubble," he said. "You have to go back to having fun."The Cardinals kept Jackson from having much fun in his bid for a third straight victory. Yadier Molina hit his fifth home run and Jake Westbrook ...
Sale struggles for White Sox in 7-4 loss to Twins

MINNEAPOLIS - Chris Sale dodged danger when a sharp comebacker in the second inning grazed his glove, then his arm and finally his chin.It eventually turned into a rough night. Even the ace of the sputtering Chicago White Sox couldn't stay out of trouble in this game.Justin Morneau homered for the first time in almost two months, a two-run shot that helped the Minnesota Twins to a 7-4 ...
Hamels hoping start vs. Mets begins turnaround

The story of the 2013 Phillies has been their inability to escape mediocrity, as they've hovered around the .500 mark almost all season. Every step forward, it seems, has been followed by a step back, and they haven't been more than one game above the break-even mark all year. They'll look to start turning things around on Friday against a familiar foe, the New York Mets, when ...
Grillis first blown save spoils Lockes start in loss

PIT@CIN: Walker makes great throw home to nab Cozart CINCINNATI -- Pirates starter Jeff Locke kept his unbeaten streak alive Wednesday at Great American Ball Park. Closer Jason Grilli couldn't say the same about his own impressive run, blowing his first save of the season en route to a 2-1 loss to the Reds in 13 innings. After Locke threw seven scoreless innings and Mark Melancon gave ...

Movie Review

Contraband

Contraband is a moderately enjoyable, generally preposterous thriller of minimal ambitions that plants Mark Wahlberg in his favorite kind of leading role: playing a tough, streetwise professional with a temper who nonetheless has a tender side beneath all the bravado (see also Th ... ...

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Natrona idea takes wing

Artist Stevo Sadvary, of Stowe Township, applies pieces of tile to a birdhouse mosaic at the Natrona Community Park and Playground in Harrison on Wednesday, June 19, ...
GOP senator’s proposal doesn’t have formula by which state stores could be shuttered

The plan by Republican Sen. Chuck McIlhinney of Bucks County allows nearly 14,000 existing liquor licensees to buy permits to sell wine and liquor. Those licensees range from beer distributors to restaurants and grocery stores with eat-in facilities, which can sell ...
Plan would keep state sole liquor wholesaler

A liquor privatization bill state Sen. Charles McIlhinney Jr., R-Doylestown, proposed would allow private companies to sell wine and spirits but would preserve Pennsylvania's role as the state's sole wholesaler. So, before a customer buys a bottle of wine from a local business, the business owner first would buy that bottle from the state, under McIlhinney's ...
FBI targets ‘hacktivist’ in rape case

A Kentucky man who drew attention to the Steubenville, Ohio, juvenile rape case said on Wednesday that the FBI is targeting him because he and other online activists seek social justice through a network of technologies that the government designed to spy on ...
Study Traffic jams siphon $1B a year from region’s drivers

In a study released on Thursday, TRIP, a Washington-based transportation research group, says congestion costs Pittsburgh-area motorists a combined $1 billion a year in lost time and wasted ...

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Making headlines

Our nuclear programmes are completely transparent. But we are ready to show greater transparency and make clear for the whole world that the steps of the Islamic Republic of Iran are completely within international frameworks. The sanctions are unfair, the Iranian people are suffering, and our (nuclear) activities are legal. These sanctions are illegal and only benefit Israel.

Hassan Rouhani

Iran's president-elect was speaking after his historic election victory.

Hotel Review

Metro Hotel on Pitt

A truly affordable hotel in Sydney, with stylish decor, great location and in-house snazzy brasserie? If the notion of affordable ...

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Pennsylvania Sun

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Featured Story

Protein key to breast cancer recurrence identified

Researchers at the Perelman School of Medicine, University of Pennsylvania have identified a key molecular player in recurrent breast cancer - a finding that suggests potential new therapeutic strategies.

The study, performed in the laboratory of Lewis A. Chodosh MD, PhD, chair of Cancer Biology and director of Cancer Genetics at the Abramson Family Cancer Research Institute, implicates the tumor suppressor protein Par-4 in recurrent breast cancer.

Par-4 is downregulated in recurrent tumors, and knocking the gene's expression down accelerates tumor recurrence in a mouse model of recurrent breast cancer. Conversely, overexpressing Par-4 delays the onset of tumor recurrence.

Data from human breast cancer patients confirm these findings. The authors analyzed patient tumors from the I-SPY 1 TRIAL, a clinical trial that measured tumor gene expression patterns and response to neoadjuvant chemotherapy.

They found that Par-4 expression is low in "residual disease" (that portion of a tumor that survives chemotherapy) compared to the primary tumor prior to treatment, and that women with low Par-4 levels in their primary tumors tend to respond less well to treatment and are more likely to experience a relapse. ...