Pennsylvania Sun news

TMZ Sopranos Actor James Gandolfini Dead

The celebrity website TMZ reports that James Gandolfini, best known for his role as Tony Soprano on "The Sopranos", died earlier today in Italy.The website says Gandolfini is believed to have suffered a heart attack. He was 51 years old. Gandolfini was in Italy to attend the 59th Taormina Film Festival in Sicily and he was scheduled to participate in a festival event this weekend. ...
Manuel will be challenged to find spot for Frandsen

Email PHILADELPHIA -- Manager Charlie Manuel likes to say that if you can hit, he will find a spot for you in his lineup. But will Manuel really find a place for Kevin Frandsen with Chase Utley expected back from the disabled list before the end of the weekend? Frandsen, who started Wednesday's game against the Nationals at second base, entered having hit .304 (14-for-46) with three ...
Bethel Park couple sue contractor in federal court

A Bethel Park couple claim in a federal lawsuit filed Wednesday that a national property management company that handles foreclosure services had a local contractor repeatedly break into their home in ...
West Virginia man accused of threatening Obama his family

A West Virginia man has been indicted on charges of threatening to kill President Obama, the first lady and their daughters, federal prosecutors in Wheeling said ...
Shell casings litter street after Knoxville shooting

KELLY, ANY NEW INFORMATION? 3 3 3 3 ZONE 3 POLICE FOUND THE VEHICLE USED IN THIS DRIVE-BY JUST A MILE AWAY IN BELTZHOOVER.IT WAS ABANDONED. POLICE SAY IT'S A RENTAL CAR AND THERE ARE NO ARRETS YET. 3 BUT THAT CAR IS NOW 3 EVIDENCE - ALONG WITH THIS.AT LEAST 26 SHELL CASINGS SCATTERED ON AMANDA AVENUE. WE'RE TOLD THE CAR WAS TRAVELING 3 AND FIRED OUT THE HITTING ALMOST SIGHT.THE FREE ...

Movie Review

Contraband

Contraband is a moderately enjoyable, generally preposterous thriller of minimal ambitions that plants Mark Wahlberg in his favorite kind of leading role: playing a tough, streetwise professional with a temper who nonetheless has a tender side beneath all the bravado (see also Th ... ...

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Teen uses cellphone to call for help after ATV flips

Blount said that the 19-year-old employee had been feeding livestock when the ATV tipped. She said he was able to use his cellphone to call another employee for ...
The sweetest treats in Harrisburg Pa.

Alicia Lawrence is a content coordinator for WebpageFX and blogs in her free time at MarCom Land. She and her husband live in Harrisburg where they enjoy visiting various farmers' markets, cooking healthy and budget-friendly meals, and finding solutions to everyday problems to make life ...
Woman hospitalized with stab wound following attack outside Upper Darby McDonalds

UPPER DARBY – A woman has been hospitalized after being stabbed by at least one juvenile outside the McDonald’s restaurant on 69th Street this afternoon, police Superintendent Michael Chitwood said.The victim reportedly was one of two women confronted by a group of juveniles outside the eatery at 133 S. 69th St. after being forced to leave the restaurant by the manager, Chitwood ...
Police W. Pa woman runs over rival

Police say 28-year-old Danielle Falcon of Everson ran over the other young woman Tuesday evening in East Huntingdon Township. That's about 40 miles southeast of ...
Pa. girl who fought for lung transplant improving

PHILADELPHIA (AP) -- The mother of a 10-year-old Pennsylvania girl whose efforts to qualify for an organ donation led to debate over how organs are allocated says she's improving after her double-lung ...

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Making headlines

Our nuclear programmes are completely transparent. But we are ready to show greater transparency and make clear for the whole world that the steps of the Islamic Republic of Iran are completely within international frameworks. The sanctions are unfair, the Iranian people are suffering, and our (nuclear) activities are legal. These sanctions are illegal and only benefit Israel.

Hassan Rouhani

Iran's president-elect was speaking after his historic election victory.

Hotel Review

Metro Hotel on Pitt

A truly affordable hotel in Sydney, with stylish decor, great location and in-house snazzy brasserie? If the notion of affordable ...

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Should tax havens be forced to lift their shroud of secrecy?

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Featured Story

Protein key to breast cancer recurrence identified

Researchers at the Perelman School of Medicine, University of Pennsylvania have identified a key molecular player in recurrent breast cancer - a finding that suggests potential new therapeutic strategies.

The study, performed in the laboratory of Lewis A. Chodosh MD, PhD, chair of Cancer Biology and director of Cancer Genetics at the Abramson Family Cancer Research Institute, implicates the tumor suppressor protein Par-4 in recurrent breast cancer.

Par-4 is downregulated in recurrent tumors, and knocking the gene's expression down accelerates tumor recurrence in a mouse model of recurrent breast cancer. Conversely, overexpressing Par-4 delays the onset of tumor recurrence.

Data from human breast cancer patients confirm these findings. The authors analyzed patient tumors from the I-SPY 1 TRIAL, a clinical trial that measured tumor gene expression patterns and response to neoadjuvant chemotherapy.

They found that Par-4 expression is low in "residual disease" (that portion of a tumor that survives chemotherapy) compared to the primary tumor prior to treatment, and that women with low Par-4 levels in their primary tumors tend to respond less well to treatment and are more likely to experience a relapse. ...