Pennsylvania Sun news

Shell casings litter street after Knoxville shooting

KELLY, ANY NEW INFORMATION? 3 3 3 3 ZONE 3 POLICE FOUND THE VEHICLE USED IN THIS DRIVE-BY JUST A MILE AWAY IN BELTZHOOVER.IT WAS ABANDONED. POLICE SAY IT'S A RENTAL CAR AND THERE ARE NO ARRETS YET. 3 BUT THAT CAR IS NOW 3 EVIDENCE - ALONG WITH THIS.AT LEAST 26 SHELL CASINGS SCATTERED ON AMANDA AVENUE. WE'RE TOLD THE CAR WAS TRAVELING 3 AND FIRED OUT THE HITTING ALMOST SIGHT.THE FREE ...
Teen uses cellphone to call for help after ATV flips

Blount said that the 19-year-old employee had been feeding livestock when the ATV tipped. She said he was able to use his cellphone to call another employee for ...
The sweetest treats in Harrisburg Pa.

Alicia Lawrence is a content coordinator for WebpageFX and blogs in her free time at MarCom Land. She and her husband live in Harrisburg where they enjoy visiting various farmers' markets, cooking healthy and budget-friendly meals, and finding solutions to everyday problems to make life ...
Woman hospitalized with stab wound following attack outside Upper Darby McDonalds

UPPER DARBY – A woman has been hospitalized after being stabbed by at least one juvenile outside the McDonald’s restaurant on 69th Street this afternoon, police Superintendent Michael Chitwood said.The victim reportedly was one of two women confronted by a group of juveniles outside the eatery at 133 S. 69th St. after being forced to leave the restaurant by the manager, Chitwood ...
Police W. Pa woman runs over rival

Police say 28-year-old Danielle Falcon of Everson ran over the other young woman Tuesday evening in East Huntingdon Township. That's about 40 miles southeast of ...

Movie Review

Murder by Numbers

Never as disturbing or evocative as it would like to be, Murder by Numbers plods through its psychological murder-mystery trappings like well-worn clothes, and the edges are definitely starting to look frayed. There are the roots of something truly disquieting here, but the film's slick, but routine Hollywood polish keeps it level and unmemorable. ...

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Pa. girl who fought for lung transplant improving

PHILADELPHIA (AP) -- The mother of a 10-year-old Pennsylvania girl whose efforts to qualify for an organ donation led to debate over how organs are allocated says she's improving after her double-lung ...
Fed suggests it’s closer to slowing bond purchases

Bernanke said the reductions would occur in "measured steps" and that the purchases could end by the middle of next year. By then, he said he thought unemployment would be around 7 ...
Girl injured in ATV accident in Butler County

Emergency crews and member of the Prospect Volunteer Fire Department were called in to help rescue the girl, who dispatchers say hit a tree at 11:50 ...
Fitch Releases Report on Philadelphia PA

Money Market Funds Explore Callable Commercial Paper in Value Search Money market funds (MMFs) are slowly increasing exposure to a relatively new short-term instrument - callable commercial paper (CP), according to Fitch Ratings. MMFs are exploring callable CP as a way to add additional yield and diversification to portfolios, as well as in response to banks' reduced appetite for providing ...
Rooney Pittsburgh could host the draft

It has been said that the reason the NFL moved its 2014 draft from the typical late-April date to mid-May is because of a conflict with an Easter show at Radio City Music Hall in New York City. It has been said there exists the probability of future conflicts at Radio City as well. It has been said the NFL could respond to this either by moving the draft into May permanently to accommodate Radio ...

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Making headlines

Our nuclear programmes are completely transparent. But we are ready to show greater transparency and make clear for the whole world that the steps of the Islamic Republic of Iran are completely within international frameworks. The sanctions are unfair, the Iranian people are suffering, and our (nuclear) activities are legal. These sanctions are illegal and only benefit Israel.

Hassan Rouhani

Iran's president-elect was speaking after his historic election victory.

Hotel Review

Metro Hotel on Pitt

A truly affordable hotel in Sydney, with stylish decor, great location and in-house snazzy brasserie? If the notion of affordable ...

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Featured Story

Protein key to breast cancer recurrence identified

Researchers at the Perelman School of Medicine, University of Pennsylvania have identified a key molecular player in recurrent breast cancer - a finding that suggests potential new therapeutic strategies.

The study, performed in the laboratory of Lewis A. Chodosh MD, PhD, chair of Cancer Biology and director of Cancer Genetics at the Abramson Family Cancer Research Institute, implicates the tumor suppressor protein Par-4 in recurrent breast cancer.

Par-4 is downregulated in recurrent tumors, and knocking the gene's expression down accelerates tumor recurrence in a mouse model of recurrent breast cancer. Conversely, overexpressing Par-4 delays the onset of tumor recurrence.

Data from human breast cancer patients confirm these findings. The authors analyzed patient tumors from the I-SPY 1 TRIAL, a clinical trial that measured tumor gene expression patterns and response to neoadjuvant chemotherapy.

They found that Par-4 expression is low in "residual disease" (that portion of a tumor that survives chemotherapy) compared to the primary tumor prior to treatment, and that women with low Par-4 levels in their primary tumors tend to respond less well to treatment and are more likely to experience a relapse. ...