Pennsylvania Sun news

Phils fall to Nats in 11 after Papelbons blown save

WSH@PHI: Phillies take early lead on M.Young's homer PHILADELPHIA -- Jayson Werth told reporters Tuesday that the Nationals needed to show up Wednesday at Citizens Bank Park "ready to eat somebody's face." Apparently he meant they needed to devour the Phillies, who had won the first two games of the three-game series between the two struggling National League East rivals. ...
Written records carry risk of skimming says accountant reviewing Pittsburgh city books

Pittsburgh still uses pencil and paper to record some cash transactions, according to a financial accountant who is examining the city's ...
Lancaster transplant patient’s battle isn’t over yet in Pittsburgh

One of Raymond New Holy's toughest battles may be trying to keep his family with him in Pittsburgh as he recuperates from a double lung transplant, friends and family members ...
Grillis save streak ends as Reds rally

Jay Bruce ended Jason Grilli's saves streak with a solo homer in the ninth, and Brandon Philips singled with the bases loaded in the 13th inning on Wednesday night, rallying the Cincinnati Reds to a 2-1 victory over the Pittsburgh ...
Collingdale mother receives prison term in son’s fatal heroin overdose

arose@delcotime.com @arosedelco MEDIA COURTHOUSE - A 29-year-old Collingdale woman was sentenced to three to six years in state prison Tuesday for the July 2012 death of her 11-month-old son from a heroin overdose.Christina Rivero was scheduled to go to trial next week on charges of third-degree murder and criminal homicide, but pleaded Tuesday to lesser charges of involuntary manslaughter and ...

Movie Review

Contraband

Contraband is a moderately enjoyable, generally preposterous thriller of minimal ambitions that plants Mark Wahlberg in his favorite kind of leading role: playing a tough, streetwise professional with a temper who nonetheless has a tender side beneath all the bravado (see also Th ... ...

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Radnor High School to drop Red Raider

Lstein@mainlinemedianews.com The Radnor High School mascot, the Red Raider, graduated in 2013 and will no longer attend football games and other sporting events.His departure was noted at the Radnor Township School Board Policy Committee meeting Tuesday, when high school Principal Mark Schellenger updated the committee. Schellenger said pictures of the departing mascot are in the 2013 ...
Chester man’s murder trial continues

MEDIA COURTHOUSE - The trial of Edwin Soto Jr., a 23-year-old Chester man accused of first-degree murder in a February 2012 shooting spree at J&S Seafood, continued Wednesday before Judge James Pagano.The question before the jury is not whether Soto shot and killed 22-year-old Jamecia I. Toler in the early hours of Feb. 19, 2012, but whether his actions amount to first- or third-degree ...
Accused car vandal blames sleepwalking

By LINDA REILLYTimes Correspondent UPPER DARBY - A township man caught on surveillance video vandalizing his neighbor’s car blamed sleepwalking, police said.Dung Tran, 32, of the 6600 block of Chestnut Street, was arrested last week for allegedly using an object to scratch the paint off a neighbor’s 2007 Lexus parked in the common driveway."The sleepwalking defense ...
Haverford hands out Recchiuti Awards

By LOIS PUGLIONESITimes Correspondent HAVERFORD - School officials recently presented the 2013 Domenick Recchiuti Humanitarian Award to district employees, community members and two high school students who went above and beyond to perform acts of community service and volunteerism this past year.Technology Director Jane Greenspun named five members of the maintenance staff, Michael McCann, ...
U.D. police investigate stabbing outside eatery

By LINDA REILLYTimes Correspondent UPPER DARBY - Police are continuing to investigate a Wednesday afternoon stabbing outside a fast food restaurant on 69th Street.A 22-year-old woman was hospitalized after being stabbed by at least one juvenile outside the McDonald’s restaurant, 69th Street, police Superintendent Michael Chitwood said.According to Chitwood, the victim reportedly was one ...

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Making headlines

Our nuclear programmes are completely transparent. But we are ready to show greater transparency and make clear for the whole world that the steps of the Islamic Republic of Iran are completely within international frameworks. The sanctions are unfair, the Iranian people are suffering, and our (nuclear) activities are legal. These sanctions are illegal and only benefit Israel.

Hassan Rouhani

Iran's president-elect was speaking after his historic election victory.

Hotel Review

Metro Hotel on Pitt

A truly affordable hotel in Sydney, with stylish decor, great location and in-house snazzy brasserie? If the notion of affordable ...

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Featured Story

Protein key to breast cancer recurrence identified

Researchers at the Perelman School of Medicine, University of Pennsylvania have identified a key molecular player in recurrent breast cancer - a finding that suggests potential new therapeutic strategies.

The study, performed in the laboratory of Lewis A. Chodosh MD, PhD, chair of Cancer Biology and director of Cancer Genetics at the Abramson Family Cancer Research Institute, implicates the tumor suppressor protein Par-4 in recurrent breast cancer.

Par-4 is downregulated in recurrent tumors, and knocking the gene's expression down accelerates tumor recurrence in a mouse model of recurrent breast cancer. Conversely, overexpressing Par-4 delays the onset of tumor recurrence.

Data from human breast cancer patients confirm these findings. The authors analyzed patient tumors from the I-SPY 1 TRIAL, a clinical trial that measured tumor gene expression patterns and response to neoadjuvant chemotherapy.

They found that Par-4 expression is low in "residual disease" (that portion of a tumor that survives chemotherapy) compared to the primary tumor prior to treatment, and that women with low Par-4 levels in their primary tumors tend to respond less well to treatment and are more likely to experience a relapse. ...