Pennsylvania Sun news

Pixar goes live with Pittsburgh Orchestra Pittsburgh Tribune-Review

Pixar Animation Studios has won 27 Academy Awards since it released "Toy Story," its first feature-length film, in 1995. Each of its 13 films, including "Finding Nemo," "The Incredibles," "Cars" and "Ratatouille," has been a hit. Now, Pixar, which was bought by Disney in 2006, has joined its parent company in creating shows that feature live ...
10 things you need to know for Thursday

C-City Blogger Presenting Chester City's news and views to Delco Times web visitors who want to know more of what's going on in the City besides the stories they read in the ...
Accused Upper Darby car vandal blames sleepwalking

By LINDA REILLYTimes Correspondent UPPER DARBY - A township man caught on surveillance video vandalizing his neighbor’s car blamed sleepwalking, police said.Dung Tran, 32, of the 6600 block of Chestnut Street, was arrested last week for allegedly using an object to scratch the paint off a neighbor’s 2007 Lexus parked in the common driveway."The sleepwalking defense ...
Newtown Square girl Sarah Murnaghan who fought for lung transplant improving

PHILADELPHIA (AP) - The mother of a 10-year-old Delaware County girl whose efforts to qualify for an organ donation led to debate over how organs are allocated says she's improving after her double-lung transplant.Janet Murnaghan (MUR'-nuh-han) says on her Facebook page her daughter Sarah was moved on Wednesday from a heavy-duty breathing machine to a traditional ventilator. She calls ...
Corbett signs Pileggi bill to abolish Philly traffic court

HARRISBURG, Pa. (AP) - Gov. Tom Corbett signed a bill Wednesday that will begin the process of dismantling the scandal-ridden Philadelphia Traffic Court.Federal authorities this year charged nine current or former Philadelphia traffic court judges with fixing tickets as political favors.Under the newly signed bill, November elections for three open seats on the seven-judge traffic court will be ...

Movie Review

Beowulf [DVD]

All hail technology and what it hath wrought! Bow down at the altar of infinitely malleable pixels and the bounty they provide: Impossible visuals! Epic landscapes! Monsters that heretofore have only resided in mans imagination! And slightly rubbery-looking humans who in close-up offer every nua ... ...

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Police find body inside burned car in Carlisle

Nearby residents had reported hearing a loud `boom' and then seeing a vehicle explode in flames. Firefighters say they had it under control in about 10 minutes and found the body badly burned ...
AP EXCLUSIVE Taliban offer to free US soldier in exchange for Afghans held at Guantanamo

FILE -- The image of Army Sgt. Bowe Bergdahl of Hailey, Idaho, who is being held captive in Afghanistan, is worn by an audience member as Bergdahl's father Bob, not pictured, speaks at the annual Rolling Thunder rally for POW/MIA awareness, in Washington, Sunday, May 27, 2012. A Taliban spokesman, Shaheen Suhail, in an exclusive telephone interview with The Associated Press from the newly ...
Tropical Storm Barry bears down on Mexicos coast

VERACRUZ, Mexico (AP) -- Tropical Storm Barry bore down on Mexico's Gulf Coast early Thursday as civil defense workers readied emergency shelters and forecasters warned of the possibility of deadly flash floods and ...
Chester votes against expanded trash pickup

jkopp@delcotimes.com @DT_JohnKopp Chester will not expand its trash collection to two pickup days per week this summer, a decision city council made in adherence to its financial recovery plan.For years, Chester residents enjoyed two days of trash collection each week during the summer months. However, the all-Democratic council opted to reduce trash collection to once per week when it awarded ...
Police Fifth-grader behind Chi 911 prank

cscharr@delcotimes.com @cindyscharr UPPER CHICHESTER - Police say it was an 11-year-old boy who phoned in a prank 911 call claiming there was a shooting at the Chichester Middle School last week.The boy, whose name was not released because of his age, was a fifth-grade student at the school.The prank sparked a massive police response to all of the schools in the Chichester School District and ...

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Making headlines

Our nuclear programmes are completely transparent. But we are ready to show greater transparency and make clear for the whole world that the steps of the Islamic Republic of Iran are completely within international frameworks. The sanctions are unfair, the Iranian people are suffering, and our (nuclear) activities are legal. These sanctions are illegal and only benefit Israel.

Hassan Rouhani

Iran's president-elect was speaking after his historic election victory.

Hotel Review

Metro Hotel on Pitt

A truly affordable hotel in Sydney, with stylish decor, great location and in-house snazzy brasserie? If the notion of affordable ...

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Should tax havens be forced to lift their shroud of secrecy?

Pennsylvania Sun

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Featured Story

Protein key to breast cancer recurrence identified

Researchers at the Perelman School of Medicine, University of Pennsylvania have identified a key molecular player in recurrent breast cancer - a finding that suggests potential new therapeutic strategies.

The study, performed in the laboratory of Lewis A. Chodosh MD, PhD, chair of Cancer Biology and director of Cancer Genetics at the Abramson Family Cancer Research Institute, implicates the tumor suppressor protein Par-4 in recurrent breast cancer.

Par-4 is downregulated in recurrent tumors, and knocking the gene's expression down accelerates tumor recurrence in a mouse model of recurrent breast cancer. Conversely, overexpressing Par-4 delays the onset of tumor recurrence.

Data from human breast cancer patients confirm these findings. The authors analyzed patient tumors from the I-SPY 1 TRIAL, a clinical trial that measured tumor gene expression patterns and response to neoadjuvant chemotherapy.

They found that Par-4 expression is low in "residual disease" (that portion of a tumor that survives chemotherapy) compared to the primary tumor prior to treatment, and that women with low Par-4 levels in their primary tumors tend to respond less well to treatment and are more likely to experience a relapse. ...