Pennsylvania Sun news

2 adults toddler killed in van crash

Police believe a driver may have fallen asleep before a crash that killed two adults and a young child Wednesday afternoon in Brady Township, Butler ...
Improving Alvarez still striking out in middle of lineup

Email CINCINNATI -- Third baseman Pedro Alvarez entered Wednesday's matchup with the Reds having reached base safely in 14 of 16 games this month. In that span, he hit five homers and accounted for 14 of his 43 RBIs, and manager Clint Hurdle said Alvarez has been showing glimpses of the player the Pirates hope he can be. "Pedro has the ability to shrink any park we play in," ...
Lefty Zagurski opts to explore free agency

Email CINCINNATI -- After being designated for assignment Saturday and clearing waivers Tuesday, left-hander Mike Zagurski opted to enter free agency. The Pirates thought they had a solid reliever in Zagurski after his Spring Training camp as a non-roster invitee. He gave the organization an even better impression as he posted a 2.14 ERA with 37 strikeouts in 21 innings for Triple-A ...
Strikeouts glaring for struggling Pirates offense

Email CINCINNATI -- Tuesday's 4-0 win against the Reds encapsulated the good and the bad surrounding the Pirates this season. Pittsburgh received more quality pitching, starting with Charlie Morton and ending with closer Jason Grilli. That's nothing new, as the Pirates entered Wednesday with a 3.29 ERA, good for third in the Majors. Unfortunately for the Pirates, the familiar ...
Manuel backs Sandbergs decisions at third

Email PHILADELPHIA -- Delmon Young is not fleet footed, but Phillies third-base coach Ryne Sandberg sent him home from second base with two outs on a single to center in the fifth inning of Tuesday's 4-2 win over the Nationals. Nationals center fielder Denard Span threw Young out at the plate, but it took a good throw to do it. Entering play Wednesday, the Phillies had 10 players make an ...

Movie Review

Contraband

Contraband is a moderately enjoyable, generally preposterous thriller of minimal ambitions that plants Mark Wahlberg in his favorite kind of leading role: playing a tough, streetwise professional with a temper who nonetheless has a tender side beneath all the bravado (see also Th ... ...

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Contractor charged with theft from Jeannette

Tim Bongiorni, former president of the now-defunct Quality Sheet Metal Erection of Avella, Washington County, walks into the office of District Justice Joe DeMarchis in Jeannette on Wednesday, June 19, ...
Pixar goes live with Pittsburgh Orchestra

Pixar Animation Studios has won 27 Academy Awards since it released "Toy Story," its first feature-length film, in 1995. Each of its 13 films, including "Finding Nemo," "The Incredibles," "Cars" and "Ratatouille," has been a ...
TMZ Sopranos Actor James Gandolfini Dead

The celebrity website TMZ reports that James Gandolfini, best known for his role as Tony Soprano on "The Sopranos", died earlier today in Italy.The website says Gandolfini is believed to have suffered a heart attack. He was 51 years old. Gandolfini was in Italy to attend the 59th Taormina Film Festival in Sicily and he was scheduled to participate in a festival event this weekend. ...
Manuel will be challenged to find spot for Frandsen

Email PHILADELPHIA -- Manager Charlie Manuel likes to say that if you can hit, he will find a spot for you in his lineup. But will Manuel really find a place for Kevin Frandsen with Chase Utley expected back from the disabled list before the end of the weekend? Frandsen, who started Wednesday's game against the Nationals at second base, entered having hit .304 (14-for-46) with three ...
Bethel Park couple sue contractor in federal court

A Bethel Park couple claim in a federal lawsuit filed Wednesday that a national property management company that handles foreclosure services had a local contractor repeatedly break into their home in ...

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Making headlines

Our nuclear programmes are completely transparent. But we are ready to show greater transparency and make clear for the whole world that the steps of the Islamic Republic of Iran are completely within international frameworks. The sanctions are unfair, the Iranian people are suffering, and our (nuclear) activities are legal. These sanctions are illegal and only benefit Israel.

Hassan Rouhani

Iran's president-elect was speaking after his historic election victory.

Hotel Review

Metro Hotel on Pitt

A truly affordable hotel in Sydney, with stylish decor, great location and in-house snazzy brasserie? If the notion of affordable ...

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Should tax havens be forced to lift their shroud of secrecy?

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Featured Story

Protein key to breast cancer recurrence identified

Researchers at the Perelman School of Medicine, University of Pennsylvania have identified a key molecular player in recurrent breast cancer - a finding that suggests potential new therapeutic strategies.

The study, performed in the laboratory of Lewis A. Chodosh MD, PhD, chair of Cancer Biology and director of Cancer Genetics at the Abramson Family Cancer Research Institute, implicates the tumor suppressor protein Par-4 in recurrent breast cancer.

Par-4 is downregulated in recurrent tumors, and knocking the gene's expression down accelerates tumor recurrence in a mouse model of recurrent breast cancer. Conversely, overexpressing Par-4 delays the onset of tumor recurrence.

Data from human breast cancer patients confirm these findings. The authors analyzed patient tumors from the I-SPY 1 TRIAL, a clinical trial that measured tumor gene expression patterns and response to neoadjuvant chemotherapy.

They found that Par-4 expression is low in "residual disease" (that portion of a tumor that survives chemotherapy) compared to the primary tumor prior to treatment, and that women with low Par-4 levels in their primary tumors tend to respond less well to treatment and are more likely to experience a relapse. ...