Pennsylvania Sun news

At least 1 killed in Reserve Township shooting

Four Americans were killed during a rocket attack at Bagram Air Base, outside of Kabul, a Pentagon official said Tuesday on the condition of ...
One of US FBIs most wanted nabbed in Mexico

CANCUN, Mexico -; A state prosecutor says one of the U.S. FBI's 10 most wanted fugitives has been arrested in the resort city of Playa del ...
Goldschmidt homers in 9th Arizona beats Marlins

Arizona Diamondbacks' Paul Goldschmidt watches his walk off home run take flight against the Miami Marlins during the ninth inning of a baseball game, Tuesday, June 18, 2013, in Phoenix. The Diamondbacks won 3-2. (AP Photo/Matt ...
Tinicum OKs bid for building demolition

TINICUM - Commissioners voted unanimously Monday to approve a bid by Ridley Excavating to raze a building at 347 N. Governor Printz Blvd., which the township purchased earlier this year and plans to maintain as open space.Ridley Excavating bid $14,800 for the work.- LAURA ...
County votes to begin to turn Centre Crest into nonprofit nursing home

BELLEFONTE - Centre County likely will be getting out of the nursing home business. Despite pleas from minority Commissioner Michael Pipe to wait, the Centre County Board of Commissioners voted 2-1 on Tuesday to begin the transfer of Centre Crest Nursing Home in Bellefonte to a nonprofit facility.County officials will identify a nine-member community board of directors and draft documents to ...

Movie Review

Reservoir Dogs

"Reservoir Dogs," the exhilarating debut film of 29-year old writer/director Quentin Tarantino, is a ballet of macho posturing, gun-pointing, and the creative uses of every four-letter word imaginable. Its testosterone level is off every chart, and it happily wallows in its own juvenile love of criminals, violence, and vulgarity. Taking a note from Sam Peckinpah, Tarantino populated his film with ... ...

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Rays absorb doubleheader sweep by Red Sox

Tampa Bay Rays' Chris Archer pitches in the first inning of the first baseball game of a doubleheader against the Boston Red Sox in Boston, Tuesday, June 18, ...
AL West-leading As beat Rangers Darvish 6-2

Facing Yu Darvish has been no problem for the Oakland Athletics. They have beaten the Texas Rangers' Japanese ace four times, more than any other ...
Pleasant surprise Locke looks to keep producing

Of the five pitchers the Pirates broke Spring Training with in late March, Jeff Locke is the only remaining right now. Because of injuries to A.J. Burnett, Wandy Rodriguez and James McDonald, the rotation has seen a major overhaul since the beginning of the season. But Locke, the No. 5 starter when the year began, has been as reliable as they come. Locke will put his 6-1 record and 2.19 ERA on ...
Kendrick looking to help Phils sweep Nats

Despite an up-and-down season, the Phillies have tread water to this point, and they may have their own division foes to thank. Philadelphia is 35-37 overall but owns an 18-9 record against the National League East. The Phillies can improve on that number with a win and three-game series sweep over the Nationals on Wednesday at Citizens Bank Park. In order to do that, the Phillies will need a ...
College teacher training found in study to be ‘industry of mediocrity’

Pennsylvania colleges are doing little to curb America's steady decline from educational powerhouse to middle-of-the-pack contender, according to a study published Tuesday by the National Council on Teacher ...

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Making headlines

Our nuclear programmes are completely transparent. But we are ready to show greater transparency and make clear for the whole world that the steps of the Islamic Republic of Iran are completely within international frameworks. The sanctions are unfair, the Iranian people are suffering, and our (nuclear) activities are legal. These sanctions are illegal and only benefit Israel.

Hassan Rouhani

Iran's president-elect was speaking after his historic election victory.

Hotel Review

Beach Rotana Hotel & Towers

I could not find the Web site for this hotel, and it was not listed on any of the Internet ...

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Should tax havens be forced to lift their shroud of secrecy?

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Protein key to breast cancer recurrence identified

Researchers at the Perelman School of Medicine, University of Pennsylvania have identified a key molecular player in recurrent breast cancer - a finding that suggests potential new therapeutic strategies.

The study, performed in the laboratory of Lewis A. Chodosh MD, PhD, chair of Cancer Biology and director of Cancer Genetics at the Abramson Family Cancer Research Institute, implicates the tumor suppressor protein Par-4 in recurrent breast cancer.

Par-4 is downregulated in recurrent tumors, and knocking the gene's expression down accelerates tumor recurrence in a mouse model of recurrent breast cancer. Conversely, overexpressing Par-4 delays the onset of tumor recurrence.

Data from human breast cancer patients confirm these findings. The authors analyzed patient tumors from the I-SPY 1 TRIAL, a clinical trial that measured tumor gene expression patterns and response to neoadjuvant chemotherapy.

They found that Par-4 expression is low in "residual disease" (that portion of a tumor that survives chemotherapy) compared to the primary tumor prior to treatment, and that women with low Par-4 levels in their primary tumors tend to respond less well to treatment and are more likely to experience a relapse. ...