Pennsylvania Sun news

Group gets OK to yarn bomb Pittsburgh bridge with knitting

to cover the Andy Warhol Bridge. The group has solicited more than 1,200 volunteers and more than 100 organizations to knit panels for the project. It's funded by grants. The bridge is expected to be draped with yarn on Aug. 10 and remain covered through Sept. 7. ...
Superior Court strikes down Curley Schultz appeals

The state’s Superior Court denied on Tuesday appeals by the lawyers for two former Penn State administrators facing obstruction of justice charges from the grand jury investigation into Jerry Sandusky.The lawyers for former athletic director Tim Curley and retired vice president Gary Schultz appealed the decision of Barry Feudale, the judge overseeing the grand jury, to throw out the ...
NCAA state lawyers to meet in court Wednesday for hearing on Penn States $60 million fine

The states Commonwealth Court will hear arguments Wednesday on a local senators lawsuit to prevent the NCAA from spending money from the $60 million fine imposed on Penn State outside Pennsylvania.The NCAA is challenging the lawsuit brought by both state Sen. Jake Corman, R-Benner Township, and state Treasurer Rob McCord. Corman sued in January and is asking the court to order that the money ...
Pa. doc faces trial in former partners shooting

LIMA, Pa. (AP) -- A suburban Philadelphia pediatrician has been held for trial on charges she fatally shot her former domestic partner and narrowly missed their 11-year-old ...
Franklin Regional library aide quits in wake of theft charges

Elizabeth Kindelberger, who faces theft charges stemming from her time as president of Heritage Elementary School's parent-teacher organization, has resigned as a library aide with the ...

Movie Review

Floating Weeds / A Story of Floating Weeds [DVD]

For auteurist critics, A Story of Floating Weeds (Ukigusa monogatari), Yasujiro Ozus 1934 film about a traveling troupe of actors, is considered the moment in which he came into his own, both aesthetically and thematically. He was already a prolific fi ... ...

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National study College teacher training is ‘industry of mediocrity’

Pennsylvania colleges are doing little to curb America's steady decline from educational powerhouse to middle-of-the-pack contender, according to a study published Tuesday by the National Council on Teacher ...
Philadelphia man allegedly cut off paraplegic mans testicles

Police said they charged a Philadelphia man with attempted murder after he allegedly stabbed a paraplegic man in the chest and cut off his testicles. Edgar Bonilla, 41, was arrested Monday after a confrontation at an assisted living facility in southwest Philadelphia, the Philadelphia Daily News reported Wednesday. Bonilla went to the facility to visit a 39-year-old woman but ended up ...
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Oakland burglary suspect caught after police search

A man who's suspected of burglarizing an Oakland home was in custody early Wednesday after a search that involved dozens of police officers canvassing the neighborhood and a hillside near the Parkway ...

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Making headlines

Our nuclear programmes are completely transparent. But we are ready to show greater transparency and make clear for the whole world that the steps of the Islamic Republic of Iran are completely within international frameworks. The sanctions are unfair, the Iranian people are suffering, and our (nuclear) activities are legal. These sanctions are illegal and only benefit Israel.

Hassan Rouhani

Iran's president-elect was speaking after his historic election victory.

Hotel Review

Metro Hotel on Pitt

A truly affordable hotel in Sydney, with stylish decor, great location and in-house snazzy brasserie? If the notion of affordable ...

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Should tax havens be forced to lift their shroud of secrecy?

Pennsylvania Sun

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Featured Story

Protein key to breast cancer recurrence identified

Researchers at the Perelman School of Medicine, University of Pennsylvania have identified a key molecular player in recurrent breast cancer - a finding that suggests potential new therapeutic strategies.

The study, performed in the laboratory of Lewis A. Chodosh MD, PhD, chair of Cancer Biology and director of Cancer Genetics at the Abramson Family Cancer Research Institute, implicates the tumor suppressor protein Par-4 in recurrent breast cancer.

Par-4 is downregulated in recurrent tumors, and knocking the gene's expression down accelerates tumor recurrence in a mouse model of recurrent breast cancer. Conversely, overexpressing Par-4 delays the onset of tumor recurrence.

Data from human breast cancer patients confirm these findings. The authors analyzed patient tumors from the I-SPY 1 TRIAL, a clinical trial that measured tumor gene expression patterns and response to neoadjuvant chemotherapy.

They found that Par-4 expression is low in "residual disease" (that portion of a tumor that survives chemotherapy) compared to the primary tumor prior to treatment, and that women with low Par-4 levels in their primary tumors tend to respond less well to treatment and are more likely to experience a relapse. ...