Pennsylvania Sun news

Actor James Gandolfini 51 dies of cardiac arrest

LOS ANGELES -- James Gandolfini's lumbering, brutish mob boss with the tortured psyche will endure as one of TV's indelible characters.But his portrayal of criminal Tony Soprano in HBO's landmark drama series "The Sopranos" was just one facet of an actor who created a rich legacy of film and stage work in a life cut short.Gandolfini, 51, who died Wednesday while ...
Official Gandolfini likely had heart attack

The body of the actor was transferred to the morgue at the Policlinico Umberto I hospital in Rome early Thursday, where it awaited an autopsy. By law, medical examiners in Italy are required to carry out the postmortem 24 hours after the body's arrival in the morgue, a hospital spokesman said. Professor Claudio Modini, head of the emergency department where the actor was taken, said he ...
Police Fifth-grader behind Chi 911 prank call that led to lockdown

cscharr@delcotimes.com @cindyscharr UPPER CHICHESTER - Police say it was an 11-year-old boy who phoned in a prank 911 call claiming there was a shooting at the Chichester Middle School last week.The boy, whose name was not released because of his age, was a fifth-grade student at the school.The prank sparked a massive police response to all of the schools in the Chichester School District and ...
Suspect in Darby Township shooting charged with attempted murder

cscharr@delcotimes.com @cindyscharr DARBY TOWNSHIP - The suspect who allegedly shot an 18-year-old man after chasing him down the street and unloading his weapons into an occupied house Monday is under arrest, charged with attempted murder.Jamal Marceau Stuckey, 18, is being held on 10 percent of $500,000 in connection with the shooting that nearly cost the victim his life, police said.Deputy ...
Uh its not OK to drive your tractor drunk in Pennsylvania and other bizarre news

One man allegedly drives a lawn tractor while intoxicated and a woman racks up two driving under the influence charges in one day. Those items and others in this edition of the bizarre blotter. Things not to ride while drunk in Pennsylvania Jerome Foltz (Southern York County Regional Police Department)A Pennsylvania man was arrested Monday for allegedly driving a lawn tractor while ...

Movie Review

The Last House on the Left (2009)

Of all the horror films from the 70s and 80s that have been remade in the last five or six years--and there have been oh-so-many--the only one that has offered a real opportunity for improvement is Wes Cravens The Last House on the Left (1972), a notorio ... ...

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Police Puppy stolen from SPCA recovered in Pa.

HAZLETON, Pa. - A puppy has been recovered after it was allegedly stolen from a northeastern Pennsylvania SPCA in a woman's purse.Investigators say the theft happened June 13 at the Luzerne County SPCA in Plains Township. Police say the woman, whose name has not been released, concealed the dog in her purse.Police in Hazleton said Tuesday that they had recovered the dog. Police Chief Frank ...
Italy hospital Gandolfini died of cardiac arrest

View Photo Associated Press/Alessandra Tarantino - Coroner Antonio Spasola speaks to the media outside the morgue of Policlinico Umberto I hospital where the body of actor James Gandolfini was brought after he died ...
Magistrate says McKeesport diner can stay

Elias plans to relocate Di's Kornerstone Diner to a former Burger King building in Olympia Shopping Center in Versailles. She hopes the new location will be open by ...
Pennsylvania college wins temporary reprieve from HHS mandate

A US district court judge has granted a Pennsylvania Christian college a temporary reprieve from the HHS insurance mandate. Objecting to the inclusion of abortifacients in the mandate, Geneva College, which is affiliated with the Reformed Presbyterian Church of North America, said in a legal filing that it objected to the mandate because "the procurement, participation in, facilitation of, ...
Police find Philadelphia bicyclist impaled on fence

PHILADELPHIA-Philadelphia police say a bicyclist is seriously injured after he was found impaled on a fence in Fairmount Park. Authorities say police found the main around 2 a.m. Thursday when they received a call that led them to Martin Luther King Drive, a main thoroughfare. They say there was a dip in the road and that the man may have lost control and fell. They found the man impaled on the ...

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Making headlines

Our nuclear programmes are completely transparent. But we are ready to show greater transparency and make clear for the whole world that the steps of the Islamic Republic of Iran are completely within international frameworks. The sanctions are unfair, the Iranian people are suffering, and our (nuclear) activities are legal. These sanctions are illegal and only benefit Israel.

Hassan Rouhani

Iran's president-elect was speaking after his historic election victory.

Hotel Review

Waldorf-Astoria Hotel New York

I clambered up the stairs with my luggage whilst two bell attendants chatted away. I entered the huge lobby of ...

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Featured Story

Protein key to breast cancer recurrence identified

Researchers at the Perelman School of Medicine, University of Pennsylvania have identified a key molecular player in recurrent breast cancer - a finding that suggests potential new therapeutic strategies.

The study, performed in the laboratory of Lewis A. Chodosh MD, PhD, chair of Cancer Biology and director of Cancer Genetics at the Abramson Family Cancer Research Institute, implicates the tumor suppressor protein Par-4 in recurrent breast cancer.

Par-4 is downregulated in recurrent tumors, and knocking the gene's expression down accelerates tumor recurrence in a mouse model of recurrent breast cancer. Conversely, overexpressing Par-4 delays the onset of tumor recurrence.

Data from human breast cancer patients confirm these findings. The authors analyzed patient tumors from the I-SPY 1 TRIAL, a clinical trial that measured tumor gene expression patterns and response to neoadjuvant chemotherapy.

They found that Par-4 expression is low in "residual disease" (that portion of a tumor that survives chemotherapy) compared to the primary tumor prior to treatment, and that women with low Par-4 levels in their primary tumors tend to respond less well to treatment and are more likely to experience a relapse. ...