Pennsylvania Sun news

Local Army National Guardsman sues Target over no show firing

A member of the Pennsylvania Army National Guard has sued Target Corp., saying he was wrongly fired from one of the chain's Pittsburgh-area stores for violating its "no call, no-show" policy while he was on a two-week training assignment in Virginia.Andrew Lanier claims in his federal lawsuit that he told his supervisors about the training duty in late October 2011.But Lanier said ...
Worker critically injured on Interstate 279

The injured man has not been identified yet. PennDOT said he is an inspection worker for a contractor and they are still unsure of what happened to ...
Communication the key to new bag rule

To those fans who are upset about the NFL's recently announced change to its bag policy, Steelers President Art Rooney II wants you to know that he's listening.The change, announced on June 13 and set to be implemented starting with preseason games in 2013, allows for each fan to being in one clear plastic or vinyl or PVC bag that cannot exceed 12-inches-by-6-inches-by-12 inches. In ...
Tinicum OKs bid for building demolition

TINICUM - Commissioners voted unanimously Monday to approve a bid by Ridley Excavating to raze a building at 347 N. Governor Printz Blvd., which the township purchased earlier this year and plans to maintain as open space.Ridley Excavating bid $14,800 for the work.- LAURA ...
Physicians group labels obesity a disease

The American Medical Association adopts a new policy on obesity The change diagnoses nearly one-third of Americas with a medical condition AMA decision could increase funding for future research, doctor ...

Movie Review

Floating Weeds / A Story of Floating Weeds [DVD]

For auteurist critics, A Story of Floating Weeds (Ukigusa monogatari), Yasujiro Ozus 1934 film about a traveling troupe of actors, is considered the moment in which he came into his own, both aesthetically and thematically. He was already a prolific fi ... ...

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Judges consider tossing $60M Penn St. fund lawsuit

HARRISBURG, Pa. (AP) -- A panel of Pennsylvania judges is considering whether to grant a request by the NCAA and throw out a lawsuit filed by a state senator and the state treasurer over the fine imposed on Penn State for its handling of the Jerry Sandusky ...
Easton Pa. school board eliminates 43 positions

The Easton Area School Board approved the cuts Tuesday. They come after the eastern Pennsylvania district voted in May to pass a $134.3 million spending plan and a 1.7 percent tax ...
Computer issue causes delays at Philly airport

PHILADELPHIA (AP) -- A computer glitch that caused delays and long lines for some American Airlines and United Airlines passengers at Philadelphia International Airport has been ...
Going green at the top of Lancaster

http://bit.ly/12KkjF4 ). The idea is to capture rainfall on the green rooftops to prevent polluted water from flowing off of buildings and into the sewer ...
Pittsburgh Council rejects expansion of Mexican War Streets historic district

Pittsburgh City Council on Wednesday unanimously rejected legislation expanding the North Side's Mexican War Streets historical district and restricting what residents could do to the exterior of their homes and ...

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Latest International News

Major General Finn appointed to top UN role in Jerusalem

18 June 2013 150 United Nations Secretary-General Ban Ki-moon announced the appointment today of Major ...
Obama welcomes Iran's election of moderate president

WASHINGTON - US President Barack Obama has urged Iran's newly elected president to prove to ...
Widespread anti-graft protests rock Brazil

SAO PAULO, Brazil - Anti-graft protests swept Brazil's main cities as some 200,000 demonstrators marched ...
No breakthrough in talks between UK and Ecuador over Assange

LONDON - Talks between the United Kingdom and Ecuador have ended without any breakthrough over ...

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Latest Pennsylvania News

Local Army National Guardsman sues Target over no show firing

A member of the Pennsylvania Army National Guard has sued Target Corp., saying he was ...
Worker critically injured on Interstate 279

The injured man has not been identified yet. PennDOT said he is an inspection worker ...
Communication the key to new bag rule

To those fans who are upset about the NFL's recently announced change to its bag ...
Tinicum OKs bid for building demolition

TINICUM - Commissioners voted unanimously Monday to approve a bid by Ridley Excavating to raze ...

Additional Pennsylvania Sun Pennsylvania News

Making headlines

Our nuclear programmes are completely transparent. But we are ready to show greater transparency and make clear for the whole world that the steps of the Islamic Republic of Iran are completely within international frameworks. The sanctions are unfair, the Iranian people are suffering, and our (nuclear) activities are legal. These sanctions are illegal and only benefit Israel.

Hassan Rouhani

Iran's president-elect was speaking after his historic election victory.

Hotel Review

Metro Hotel on Pitt

A truly affordable hotel in Sydney, with stylish decor, great location and in-house snazzy brasserie? If the notion of affordable ...

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Should tax havens be forced to lift their shroud of secrecy?

Pennsylvania Sun

Pennsylvania Sun | Reporting the News in Pennsylvania

Every minute of every day our news editors canvass the issues, and stories making the news to provide our readers with a broad and in-depth coverage of what's happening in the world.

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Featured Story

Protein key to breast cancer recurrence identified

Researchers at the Perelman School of Medicine, University of Pennsylvania have identified a key molecular player in recurrent breast cancer - a finding that suggests potential new therapeutic strategies.

The study, performed in the laboratory of Lewis A. Chodosh MD, PhD, chair of Cancer Biology and director of Cancer Genetics at the Abramson Family Cancer Research Institute, implicates the tumor suppressor protein Par-4 in recurrent breast cancer.

Par-4 is downregulated in recurrent tumors, and knocking the gene's expression down accelerates tumor recurrence in a mouse model of recurrent breast cancer. Conversely, overexpressing Par-4 delays the onset of tumor recurrence.

Data from human breast cancer patients confirm these findings. The authors analyzed patient tumors from the I-SPY 1 TRIAL, a clinical trial that measured tumor gene expression patterns and response to neoadjuvant chemotherapy.

They found that Par-4 expression is low in "residual disease" (that portion of a tumor that survives chemotherapy) compared to the primary tumor prior to treatment, and that women with low Par-4 levels in their primary tumors tend to respond less well to treatment and are more likely to experience a relapse. ...