Pennsylvania Sun news

De La Rosa sharp but Rockies lose to Blue Jays 2-0

Colorado Rockies pitcher Jorge De La Rosa works against the Toronto Blue Jays during the first inning of a baseball game in Toronto, Monday June 17, 2013. (AP Photo/The Canadian Press, Frank ...
Porter sends Miss. St. to 5-4 CWS win over Indiana

Mississippi State's Wes Rea, left, and Demarcus Henderson, right, celebrate their go-ahead runs on a single by Trey Porter against Indiana in the eighth inning of an NCAA College World Series game in Omaha, Neb., Monday, June 17, 2013. (AP Photo/Ted ...
Wild pitch dooms Indians in 2-1 loss to Royals

Fans walk their dogs around Progressive Field before a baseball game between the Kansas City Royals and the Cleveland Indians Monday, June 17, 2013, in Cleveland. The Indians held their "Puppypalooza" promotion where fans and their canine friends sit in a special section for the ...
Miller Molina lead Cardinals to victory

Rookie Shelby Miller pitched five shutout innings and Yadier Molina had a two-run double to lead the St. Louis Cardinals to a 5-2 win over the Chicago Cubs on Monday ...
Tracy ties it in 9th but Phils win in bottom half

PHILADELPHIA — Chad Tracy provided a surge in the Washington dugout, though the good feelings were short-lived. After Tracy's homer with two outs in the top of the ninth inning tied the game, Domonic Brown hit an RBI single with two outs in the bottom of the ninth and the Philadelphia Phillies beat the Nationals 5-4 on Monday night. The Nationals tied it at 4 when Tracy hit a solo ...

Movie Review

Gladiator

After several years of major releases, it has finally become clear what the DreamWorks strategy is: Each summer, they try to revive some long-dormant Hollywood genre by giving it a splashy, special-effects-laden modern spin. In 1998, they successfully revived the flag-waving World War II epic with Steven Spielberg's "Saving Private Ryan." Last summer, they tried (with considerably less success) t ... ...

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Strong effort from Liriano derailed by home runs

PIT@CIN: Marte dives to rob Phillips of extra bases CINCINNATI -- With a chance to move into second place in the National League Central by beating the team in front of them, the Pirates fell just short on Monday, losing to the Reds 4-1 at Great American Ball Park. Francisco Liriano surrendered two solo home runs and the Pittsburgh offense couldn't do much against Mike Leake and the ...
Morton faces Latos looking to continue Bucs quirky trend

On Monday, the Pirates dropped the first game of their four-game set against the Reds at Great American Ball Park. But don't worry, it's all part of their plan. In each of their five four-game series this season (counting a two-game home and home with the Tigers), the Bucs lost the first game and came back to win the next three. They'll try to continue this strange trend, one ...
Chief touts transit as improved

Port Authority of Allegheny County's chief executive tried to mend the agency's poor reputation with some legislators in testimony Monday to the state House Transportation ...
Awards honor 3 teenagers’ achievements

Although silver and bronze medals also are awarded, to achieve the highest honor, participants must dedicate 800 hours to voluntary public service (400 hours), personal development (200 hours) and physical fitness (200 hours). Four consecutive nights must be spent on expedition/exploration -- an outdoor, wilderness or adventure ...
Historic district expansion divides North Side residents

Longtime Mexican War Streets resident Michele Johnson heads to a community meeting Monday, June 17, 2013 on the North Side. More than 30 residents attended a cookout in opposition to expanding the Historic District boundries and then marched to the ...

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Making headlines

Our nuclear programmes are completely transparent. But we are ready to show greater transparency and make clear for the whole world that the steps of the Islamic Republic of Iran are completely within international frameworks. The sanctions are unfair, the Iranian people are suffering, and our (nuclear) activities are legal. These sanctions are illegal and only benefit Israel.

Hassan Rouhani

Iran's president-elect was speaking after his historic election victory.

Hotel Review

Amora Hotel Jamison Sydney

This hotel is located right in the heart of the CBD of Sydney in Jamison Street. The hotel neighbours the ...

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Featured Story

Protein key to breast cancer recurrence identified

Researchers at the Perelman School of Medicine, University of Pennsylvania have identified a key molecular player in recurrent breast cancer - a finding that suggests potential new therapeutic strategies.

The study, performed in the laboratory of Lewis A. Chodosh MD, PhD, chair of Cancer Biology and director of Cancer Genetics at the Abramson Family Cancer Research Institute, implicates the tumor suppressor protein Par-4 in recurrent breast cancer.

Par-4 is downregulated in recurrent tumors, and knocking the gene's expression down accelerates tumor recurrence in a mouse model of recurrent breast cancer. Conversely, overexpressing Par-4 delays the onset of tumor recurrence.

Data from human breast cancer patients confirm these findings. The authors analyzed patient tumors from the I-SPY 1 TRIAL, a clinical trial that measured tumor gene expression patterns and response to neoadjuvant chemotherapy.

They found that Par-4 expression is low in "residual disease" (that portion of a tumor that survives chemotherapy) compared to the primary tumor prior to treatment, and that women with low Par-4 levels in their primary tumors tend to respond less well to treatment and are more likely to experience a relapse. ...