Pennsylvania Sun news

Man 76 killed in multivehicle crash

Two other drivers -- a 73-year-old man and a 28-year-old woman -- were flown to Ruby Memorial Hospital in Morgantown, W.Va., with moderate injuries, police ...
Flash flooding stalls cars pushes others downstream

She said flooding dumped several feet of water into her basement two years ago, and that sewers often fill up quickly from the runoff. The flooding along Constitution Boulevard has since receded, but debris remained in the ...
Rays struggle against Aceves lose 5-1 to Boston

Tampa Bay Rays' Chris Archer pitches in the first inning of the first baseball game of a doubleheader against the Boston Red Sox in Boston, Tuesday, June 18, 2013. (AP Photo/Michael ...
Oklahoma executes inmate for couples 2000 deaths

McALESTER, Okla. -- Oklahoma executed a 36-year-old man on Tuesday for taking part in the brutal killing of a ranching couple 13 years ago.James Lewis DeRosa was killed by lethal injection at the Oklahoma State Penitentiary in McAlester, becoming the state's second inmate executed this year.At a clemency hearing last month, DeRosa took responsibility for his role in the Oct. 2, 2000, ...
Walker questions intent of Chapmans chin music

Email CINCINNATI -- In the ninth inning of Monday's 4-1 loss to the Reds, Neil Walker led off against Cincinnati closer Aroldis Chapman. With the count even at two balls and two strikes, Chapman buzzed a 100-mph fastball right past the chin of Walker, who barely evaded it and fell to his back. Walker popped up and struck out swinging on the next pitch, and that was the end of it. Except ...

Movie Review

Reservoir Dogs

"Reservoir Dogs," the exhilarating debut film of 29-year old writer/director Quentin Tarantino, is a ballet of macho posturing, gun-pointing, and the creative uses of every four-letter word imaginable. Its testosterone level is off every chart, and it happily wallows in its own juvenile love of criminals, violence, and vulgarity. Taking a note from Sam Peckinpah, Tarantino populated his film with ... ...

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Eligible to return Gomez makes second rehab start

Email CINCINNATI -- Injured right-hander Jeanmar Gomez was expected to make his second rehab start Tuesday with Triple-A Indianapolis as he recovers from a right forearm strain and inflammation. The goal, manager Clint Hurdle said, was for Gomez to throw 65-70 pitches in about five innings. "We want to make sure he gets up and down five times," Hurdle said. "Unless the pitch ...
Andy Warhol Bridge to be covered in knitted blankets in August

Council on Tuesday approved the Knit-the-Bridge public art project, which involves more than 1,200 people in knitting groups at schools, nursing homes and even the Shuman Juvenile Detention Center preparing blankets to cover the former Seventh Street Bridge that spans the Allegheny ...
Award-Winning Journalist Michael Hastings Dies

Michael Hastings of BuzzFeed and Rolling Stone attends the Guardian’s ';Post-Truth Politics & The Media’s Role'; reception and discussion at The LongView Gallery on May 1, 2012, in Washington, DC. (credit: Paul Morigi/Getty Images for The ...
Oly sprinter Campbell-Brown suspended amid probe

KINGSTON, Jamaica - Veronica Campbell-Brown's agent insists one of the cornerstones of Jamaica's wide-ranging sprint success "is not a cheat," even though the test results disagree.While her case is being decided, the three-time Olympic gold medalist will sit out and her country will try to make sense of one of its longest-held fears: a high-profile track star getting busted ...
Revere securing hold on Phils leadoff spot

Email PHILADELPHIA -- Nine days ago, Ben Revere was hitting .244. Eight games and 16 hits later, his season average was up to .274 heading into Tuesday's game against Washington. Revere hit safely in each of those eight games and was 16-for-37 (.432) in that span. The center fielder has four multi-hit games in those contests, including a two-hit performance in the series opener against the ...

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Making headlines

Our nuclear programmes are completely transparent. But we are ready to show greater transparency and make clear for the whole world that the steps of the Islamic Republic of Iran are completely within international frameworks. The sanctions are unfair, the Iranian people are suffering, and our (nuclear) activities are legal. These sanctions are illegal and only benefit Israel.

Hassan Rouhani

Iran's president-elect was speaking after his historic election victory.

Hotel Review

Beach Rotana Hotel & Towers

I could not find the Web site for this hotel, and it was not listed on any of the Internet ...

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Protein key to breast cancer recurrence identified

Researchers at the Perelman School of Medicine, University of Pennsylvania have identified a key molecular player in recurrent breast cancer - a finding that suggests potential new therapeutic strategies.

The study, performed in the laboratory of Lewis A. Chodosh MD, PhD, chair of Cancer Biology and director of Cancer Genetics at the Abramson Family Cancer Research Institute, implicates the tumor suppressor protein Par-4 in recurrent breast cancer.

Par-4 is downregulated in recurrent tumors, and knocking the gene's expression down accelerates tumor recurrence in a mouse model of recurrent breast cancer. Conversely, overexpressing Par-4 delays the onset of tumor recurrence.

Data from human breast cancer patients confirm these findings. The authors analyzed patient tumors from the I-SPY 1 TRIAL, a clinical trial that measured tumor gene expression patterns and response to neoadjuvant chemotherapy.

They found that Par-4 expression is low in "residual disease" (that portion of a tumor that survives chemotherapy) compared to the primary tumor prior to treatment, and that women with low Par-4 levels in their primary tumors tend to respond less well to treatment and are more likely to experience a relapse. ...