Pennsylvania Sun news

APNewsBreak Conn. chimp attack victim to appeal

NEW HAVEN, Conn. -; An attorney for a Connecticut woman disfigured by a friend's pet chimpanzee says he plans to appeal a decision denying her permission to sue the state for $150 million on her claim officials knew the chimp was dangerous but didn't do anything about ...
Suit McDonalds wages put on costly debit card

Single mom Natalie Gunshannon has filed suit over bank fees that allegedly include $1.00 to check her balance, $1.50 to withdraw cash and $15 to replace a lost ...
Poll Congress approval rating just 16 percent

According to a new national poll, just 16 percent of Americans approve of the way Congress is handling its job, with 83 percent of those questioned in a CNN/ORC International survey saying they disapprove. The poll was released ...
Union presents plan to save jobs at GE Erie plant

ERIE, Pa. (AP) -- Union officials presented a plan Tuesday to keep 950 jobs at a General Electric Transportation plant in Erie, but the company cast doubt on the ...
Senator’s liquor plan offers sales packaging reform but no state store closings

HARRISBURG -- A Bucks County senator, flanked by Republican leaders, on Tuesday offered a plan that he says would allow existing liquor licensees to sell wine and liquor to go, though he acknowledged his bill has no mechanism to force closure of more than 600 state-controlled ...

Movie Review

Bad Education (La mala educación)

In Bad Education (La mala educacin), Pedro Almodvars deeply saturated noir/melodrama pastiche, past and present, fiction, and truth are so intertwined and turned around that any sense of mystery the film develops is ultimately subsumed by its incessant obsession with unkno ... ...

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Bad weather barrels through Western Pa.

The storm - packing up to 40 mph wind gusts, torrential rains and possibly nickel-sized hail - is expected to impact Allegheny, Armstrong, Fayette, Washington and Westmoreland counties, weather service meteorologists ...
Penn State scandal defendants lose second appeal

Penn State's former vice president and former athletic director are facing a second loss in state appeals court, nearly two weeks after the Pennsylvania Supreme Court ruled against ...
Fitch Releases Report on Pennsylvania State System of Higher Education PA

Fitch: Market Moves Bring Bank Interest Rate Risks to Forefront The recent rise in U.S. Treasury yields and speculation surrounding possible changes in the Fed's bond buying program have highlighted the potential risks faced by U.S. banks in a rising rate environment, according to Fitch Ratings. A sustained increase in interest rates, potentially signaling an end to the prolonged low rate ...
Judge sets Fort Hood suspect trial for July 9

FORT HOOD, Texas -; Jury selection will start July 9 in the murder trial of the Army psychiatrist charged in the deadly 2009 Fort Hood shooting ...
Montreal interim mayor resigns after fraud arrest

Montreal Mayor Michael Applebaum announces his resignation a day after his arrest on fraud charges, Tuesday, June 18, 2013, at a news conference in Montreal. Applebaum had vowed to clean up the corruption scandals rocking the city. He faces 14 charges, including defrauding the government and corruption in municipal affairs. (AP Photo/The Canadian Press, Ryan ...

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Making headlines

Our nuclear programmes are completely transparent. But we are ready to show greater transparency and make clear for the whole world that the steps of the Islamic Republic of Iran are completely within international frameworks. The sanctions are unfair, the Iranian people are suffering, and our (nuclear) activities are legal. These sanctions are illegal and only benefit Israel.

Hassan Rouhani

Iran's president-elect was speaking after his historic election victory.

Hotel Review

Beach Rotana Hotel & Towers

I could not find the Web site for this hotel, and it was not listed on any of the Internet ...

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Should tax havens be forced to lift their shroud of secrecy?

Pennsylvania Sun

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Featured Story

Protein key to breast cancer recurrence identified

Researchers at the Perelman School of Medicine, University of Pennsylvania have identified a key molecular player in recurrent breast cancer - a finding that suggests potential new therapeutic strategies.

The study, performed in the laboratory of Lewis A. Chodosh MD, PhD, chair of Cancer Biology and director of Cancer Genetics at the Abramson Family Cancer Research Institute, implicates the tumor suppressor protein Par-4 in recurrent breast cancer.

Par-4 is downregulated in recurrent tumors, and knocking the gene's expression down accelerates tumor recurrence in a mouse model of recurrent breast cancer. Conversely, overexpressing Par-4 delays the onset of tumor recurrence.

Data from human breast cancer patients confirm these findings. The authors analyzed patient tumors from the I-SPY 1 TRIAL, a clinical trial that measured tumor gene expression patterns and response to neoadjuvant chemotherapy.

They found that Par-4 expression is low in "residual disease" (that portion of a tumor that survives chemotherapy) compared to the primary tumor prior to treatment, and that women with low Par-4 levels in their primary tumors tend to respond less well to treatment and are more likely to experience a relapse. ...