Pennsylvania Sun news

Rooney Pittsburgh could host the draft

It has been said that the reason the NFL moved its 2014 draft from the typical late-April date to mid-May is because of a conflict with an Easter show at Radio City Music Hall in New York City. It has been said there exists the probability of future conflicts at Radio City as well. It has been said the NFL could respond to this either by moving the draft into May permanently to accommodate Radio ...
State College auto dealer Five Star to stop selling Suzukis

Five Star Suzuki in State College will not be selling Suzukis as of this Friday, the auto dealership’s general manager said Wednesday.Five Star, at 1400 W. College Ave., opened in 2011, selling the Suzuki brand as well as used cars. In November, American Suzuki Motor Corp. filed for Chapter 11 bankruptcy, notifying all of its U.S. dealers that it would discontinue new car deliveries. The ...
Mother of lung transplant girl gives update

The Murnaghan family's quest to qualify their daughter for an organ transplant using adult lungs spurred public debate over how donor organs are ...
Villanova locked down due to robbery suspect

VILLANOVA, Pa. (AP) -- A Villanova University spokesman says the school has been locked down as police search for an armed robbery suspect near ...
Worker hurt on East Ohio Street bridge

Co-workers discovered the man pinned between the basket of a lift and the underside bridge girder, according to the Pennsylvania State Police. Co-workers lowered the man. An ambulance took him to Allegheny General Hospital for ...

Movie Review

Murder by Numbers

Never as disturbing or evocative as it would like to be, Murder by Numbers plods through its psychological murder-mystery trappings like well-worn clothes, and the edges are definitely starting to look frayed. There are the roots of something truly disquieting here, but the film's slick, but routine Hollywood polish keeps it level and unmemorable. ...

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Woman charged with running over young mother in love triangle

, 28, is facing a number of assault charges as well as criminal attempted homicide after state police in Greensburg say she intentionally ran over Katelin Hiltabidel in an East Huntingdon Township yard Tuesday ...
Thousands of tea party activists rip IRS at rally

Thousands of tea party activists gathered Wednesday outside the Capitol in loud protest of the Internal Revenue Service, seeking to keep the beleaguered agency's scandal afloat nearly six weeks after the news first ...
Corbett signals hell try to help Philly schools

HARRISBURG, Pa. (AP) -- Gov. Tom Corbett is signaling that he's engaged in efforts to help the financially troubled Philadelphia School District, which is in the midst of shedding 20 percent of its ...
Funding for key gas drilling health study stalled

Geisinger Health System spokeswoman Amanda O'Rourke said Wednesday the $1 million grant that was announced in February 2012 remains the only funding for a project that was projected to cost at least $25 ...
Army National Guardsman sues Target claims he was fired while preparing for deployment

Andrew Lanier remembers well the date that Target fired him from his stock job at its North Fayette store: Oct. 31, 2011. That's the day he learned his mission was canceled, after two weeks of training at Ft. Picket, Va., as part of his preparation for deployment to ...

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Making headlines

Our nuclear programmes are completely transparent. But we are ready to show greater transparency and make clear for the whole world that the steps of the Islamic Republic of Iran are completely within international frameworks. The sanctions are unfair, the Iranian people are suffering, and our (nuclear) activities are legal. These sanctions are illegal and only benefit Israel.

Hassan Rouhani

Iran's president-elect was speaking after his historic election victory.

Hotel Review

Metro Hotel on Pitt

A truly affordable hotel in Sydney, with stylish decor, great location and in-house snazzy brasserie? If the notion of affordable ...

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Should tax havens be forced to lift their shroud of secrecy?

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Featured Story

Protein key to breast cancer recurrence identified

Researchers at the Perelman School of Medicine, University of Pennsylvania have identified a key molecular player in recurrent breast cancer - a finding that suggests potential new therapeutic strategies.

The study, performed in the laboratory of Lewis A. Chodosh MD, PhD, chair of Cancer Biology and director of Cancer Genetics at the Abramson Family Cancer Research Institute, implicates the tumor suppressor protein Par-4 in recurrent breast cancer.

Par-4 is downregulated in recurrent tumors, and knocking the gene's expression down accelerates tumor recurrence in a mouse model of recurrent breast cancer. Conversely, overexpressing Par-4 delays the onset of tumor recurrence.

Data from human breast cancer patients confirm these findings. The authors analyzed patient tumors from the I-SPY 1 TRIAL, a clinical trial that measured tumor gene expression patterns and response to neoadjuvant chemotherapy.

They found that Par-4 expression is low in "residual disease" (that portion of a tumor that survives chemotherapy) compared to the primary tumor prior to treatment, and that women with low Par-4 levels in their primary tumors tend to respond less well to treatment and are more likely to experience a relapse. ...