Pennsylvania Sun news

Share your favorite homemade ice cream shops

Few things can satisfy on a hot summer day like homemade ice cream. WTAE Channel 4 Action News wanted to highlight a few of our newsroom's favorite places, and we want you to share your favorite hot spots for cool treats. Comment at the bottom of this story or ...
Franklin Park schedules ‘clean-fill’ project hearings in July August

A public hearing Wednesday on a municipal authority's application to build a "clean-fill" site in Franklin Park will be continued at council meetings in July and ...
Phase 2 begins at former Riverside Lounge in West Newton

This is an architect's rendering of how the property formerly known as the Riverside Lounge will look when its renovation is complete. The Progress Fund hopes to have the building ready for leasing in the fall of ...
Piano from former Sutersville Elementary School may be sold

The brown Kimball upright piano that Sutersville Borough inherited when it acquired the former Sutersville Elementary School from the Yough School District, could be up for sale, but not before the borough council learns whether senior citizens meeting at the community center want to use ...
Mt. Pleasant VFD Street Fair starts Monday

"When the new club was built in 1974, they moved the fair to Smithfield Street because of the large parking area and the air-conditioned hall that they could use for bingo," Lucia ...

Movie Review

Contraband

Contraband is a moderately enjoyable, generally preposterous thriller of minimal ambitions that plants Mark Wahlberg in his favorite kind of leading role: playing a tough, streetwise professional with a temper who nonetheless has a tender side beneath all the bravado (see also Th ... ...

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JM Computer Repair opens in Mt. Pleasant

Jason and Netah Serock of Scottdle, along with Jason's brother, Gary Michael Serock Jr. of Uniontown (not pictured) are co-owners of the recently opened J&M Computer Repair business at 502 W. Main St. in Mt. Pleasant. Photo taken Tuesday, June 11, ...
Fine art show is coming to Mt. Pleasant Public Library

Mt Pleasant Public Library Director Mary Lou Schick of Mt Pleasant Township gathers some of the art that has been submitted in preparation for 'Art and Soul, a Fine Art Show.' The fundraiser, which begins Saturday and runs through July 15, is sponsored by the Friends of the Mt Pleasant Public Library. All art will be available for ...
Yough directors bump tax rate

The Yough School Board voted last week to approve the final 2013-14 budget and with it a 1.7-mill tax increase. Revenues are projected to be $28,784,486 -- leaving a million-dollar-plus ...
Fines increased for false alarms in Donegal Township

The township's board of supervisors recently approved a new ordinance, one that replaces an prior ordinance, to more effectively classify the fees to be doled out for false alarms responded to by the Chestnut Ridge Volunteer Fire ...
Founder’s Day celebration slated for West Overton Villages

Brian Corcoran, president of the West Overton Museums board of directors, stands by one of the many new displays now featured in the distillery ...

More Pennsylvania Sun news

Making headlines

Our nuclear programmes are completely transparent. But we are ready to show greater transparency and make clear for the whole world that the steps of the Islamic Republic of Iran are completely within international frameworks. The sanctions are unfair, the Iranian people are suffering, and our (nuclear) activities are legal. These sanctions are illegal and only benefit Israel.

Hassan Rouhani

Iran's president-elect was speaking after his historic election victory.

Hotel Review

Metro Hotel on Pitt

A truly affordable hotel in Sydney, with stylish decor, great location and in-house snazzy brasserie? If the notion of affordable ...

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Have Your Say

Should tax havens be forced to lift their shroud of secrecy?

Pennsylvania Sun

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Featured Story

Protein key to breast cancer recurrence identified

Researchers at the Perelman School of Medicine, University of Pennsylvania have identified a key molecular player in recurrent breast cancer - a finding that suggests potential new therapeutic strategies.

The study, performed in the laboratory of Lewis A. Chodosh MD, PhD, chair of Cancer Biology and director of Cancer Genetics at the Abramson Family Cancer Research Institute, implicates the tumor suppressor protein Par-4 in recurrent breast cancer.

Par-4 is downregulated in recurrent tumors, and knocking the gene's expression down accelerates tumor recurrence in a mouse model of recurrent breast cancer. Conversely, overexpressing Par-4 delays the onset of tumor recurrence.

Data from human breast cancer patients confirm these findings. The authors analyzed patient tumors from the I-SPY 1 TRIAL, a clinical trial that measured tumor gene expression patterns and response to neoadjuvant chemotherapy.

They found that Par-4 expression is low in "residual disease" (that portion of a tumor that survives chemotherapy) compared to the primary tumor prior to treatment, and that women with low Par-4 levels in their primary tumors tend to respond less well to treatment and are more likely to experience a relapse. ...