Pennsylvania Sun news

Warnings issued after several woman are attacked in broad daylight

The woman said that her attacker sprayed hairspray on the back of her neck, while she was on her cellphone, then reached for the phone. She said she fought for her phone, then finally let go, in fear. She said when the man ran, she and several others chased him, then held him down until police ...
Pa. House Dems fail to slow charity-tax amendment

HARRISBURG, Pa. (AP) -- Minority Democrats in the state House of Representatives failed to slow a constitutional amendment at the center of a power struggle between the legislative and judicial ...
North Carolina Ousts Tigers From CWS With 4-2 Win

OMAHA, Neb. ...
Pitt research facility dedicated in Hill District

University of Pittsburgh Physical Activity and Weight Management Research Center assistant professor Renee Rogers demonstrates how to take exercise blood pressure as interventionist doctoral student Jackie Nagle, 25 of Greenfield works out on a treadmill at the Physical Activity and Weight Management Research Center at Oak Hill Commons in the Upper Hill ...
APNewsBreak Conn. chimp attack victim to appeal

NEW HAVEN, Conn. -; An attorney for a Connecticut woman disfigured by a friend's pet chimpanzee says he plans to appeal a decision denying her permission to sue the state for $150 million on her claim officials knew the chimp was dangerous but didn't do anything about ...

Movie Review

Bad Education (La mala educación)

In Bad Education (La mala educacin), Pedro Almodvars deeply saturated noir/melodrama pastiche, past and present, fiction, and truth are so intertwined and turned around that any sense of mystery the film develops is ultimately subsumed by its incessant obsession with unkno ... ...

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Suit McDonalds wages put on costly debit card

Single mom Natalie Gunshannon has filed suit over bank fees that allegedly include $1.00 to check her balance, $1.50 to withdraw cash and $15 to replace a lost ...
Poll Congress approval rating just 16 percent

According to a new national poll, just 16 percent of Americans approve of the way Congress is handling its job, with 83 percent of those questioned in a CNN/ORC International survey saying they disapprove. The poll was released ...
Union presents plan to save jobs at GE Erie plant

ERIE, Pa. (AP) -- Union officials presented a plan Tuesday to keep 950 jobs at a General Electric Transportation plant in Erie, but the company cast doubt on the ...
Senator’s liquor plan offers sales packaging reform but no state store closings

HARRISBURG -- A Bucks County senator, flanked by Republican leaders, on Tuesday offered a plan that he says would allow existing liquor licensees to sell wine and liquor to go, though he acknowledged his bill has no mechanism to force closure of more than 600 state-controlled ...
Bad weather barrels through Western Pa.

The storm - packing up to 40 mph wind gusts, torrential rains and possibly nickel-sized hail - is expected to impact Allegheny, Armstrong, Fayette, Washington and Westmoreland counties, weather service meteorologists ...

More Pennsylvania Sun news

Making headlines

Our nuclear programmes are completely transparent. But we are ready to show greater transparency and make clear for the whole world that the steps of the Islamic Republic of Iran are completely within international frameworks. The sanctions are unfair, the Iranian people are suffering, and our (nuclear) activities are legal. These sanctions are illegal and only benefit Israel.

Hassan Rouhani

Iran's president-elect was speaking after his historic election victory.

Hotel Review

Beach Rotana Hotel & Towers

I could not find the Web site for this hotel, and it was not listed on any of the Internet ...

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Should tax havens be forced to lift their shroud of secrecy?

Pennsylvania Sun

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Featured Story

Protein key to breast cancer recurrence identified

Researchers at the Perelman School of Medicine, University of Pennsylvania have identified a key molecular player in recurrent breast cancer - a finding that suggests potential new therapeutic strategies.

The study, performed in the laboratory of Lewis A. Chodosh MD, PhD, chair of Cancer Biology and director of Cancer Genetics at the Abramson Family Cancer Research Institute, implicates the tumor suppressor protein Par-4 in recurrent breast cancer.

Par-4 is downregulated in recurrent tumors, and knocking the gene's expression down accelerates tumor recurrence in a mouse model of recurrent breast cancer. Conversely, overexpressing Par-4 delays the onset of tumor recurrence.

Data from human breast cancer patients confirm these findings. The authors analyzed patient tumors from the I-SPY 1 TRIAL, a clinical trial that measured tumor gene expression patterns and response to neoadjuvant chemotherapy.

They found that Par-4 expression is low in "residual disease" (that portion of a tumor that survives chemotherapy) compared to the primary tumor prior to treatment, and that women with low Par-4 levels in their primary tumors tend to respond less well to treatment and are more likely to experience a relapse. ...